Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
Adv Exp Med Biol. 2010;708:66-79. doi: 10.1007/978-1-4419-8059-5_4.
Earthworms belonging to oligochaete annelids became a model for comparative immunologists in the early sixties with the publication of results from transplantation experiments that proved the existence of self/nonself recognition in earthworms. This initiated extensive studies on the earthworm immune mechanisms that evolved to prevent the invasion of pathogens. In the last four decades important cellular and humoral pathways were described and numerous biologically active compounds were characterized and often cloned.
六十年代初，随着移植实验结果的发表，证明了寡毛环节动物蚯蚓存在自我/非自我识别，蚯蚓成为比较免疫学家的模型。这就启动了对蚯蚓免疫机制的广泛研究，这些机制的进化是为了防止病原体的入侵。在过去的四十年中，已经描述了重要的细胞和体液途径，并对许多具有生物活性的化合物进行了鉴定和克隆。
