Department of Public Health, Kinki University Faculty of Medicine, 377-2 Oono-higashi, Osaka-Sayama, Osaka 589-8511, Japan.
Bone. 2011 Aug;49(2):275-80. doi: 10.1016/j.bone.2011.04.010. Epub 2011 Apr 21.
There are no data concerning a relationship between alcohol and bone status from a large-scale community-based study of elderly Japanese men. The baseline survey for the Fujiwara-kyo Osteoporosis Risk in Men Study was performed in 2174 male participants during the period from 2007 to 2008 in Nara Prefecture, Japan. Among them 1665 fitted the following inclusion criteria: (a) age ≥65years, (b) no diseases or drug therapy that could affect bone mineral density (BMD). We analyzed 1421 men with complete information about alcohol intake. We found that alcohol intake and BMD were positively correlated after adjustment for age, body mass index, natto intake, milk intake, smoking, physical activity, education, marital status, and hypertension. Adjusted total hip BMD of men with alcohol intake >39g/day was 0.90g/cm(2) and that of abstainers was 0.85g/cm(2). With regard to bone turnover markers, alcohol intake was inversely associated with serum levels of osteocalcin and tartrate-resistant acid phosphatase isoenzyme 5b. A two-piece linear regression model revealed a positive relationship between alcohol intake and crude mean BMD for the total hip in those with alcohol intake of less than 55g/day. In contrast, alcohol intake and BMD in those with an alcohol intake of 55g/day or more was inversely correlated. The present large-scale study of elderly Japanese men revealed that although an alcohol intake of <55g/day was positively correlated to BMD, alcohol intake of ≥55g/day was inversely correlated to BMD.
目前尚无来自日本老年男性大规模社区研究的关于酒精与骨量之间关系的数据。富山骨量与男性风险研究的基线调查于 2007 年至 2008 年在日本奈良县对 2174 名男性参与者进行。其中 1665 名符合以下纳入标准：（a）年龄≥65 岁，（b）无影响骨矿物质密度（BMD）的疾病或药物治疗。我们分析了 1421 名有完整酒精摄入量信息的男性。我们发现，在调整年龄、体重指数、纳豆摄入量、牛奶摄入量、吸烟、体力活动、教育、婚姻状况和高血压后，酒精摄入量与 BMD 呈正相关。每天摄入酒精>39g 的男性的总髋部 BMD 为 0.90g/cm(2)，而不饮酒者为 0.85g/cm(2)。关于骨转换标志物，酒精摄入量与血清骨钙素和抗酒石酸酸性磷酸酶 5b 呈负相关。两段线性回归模型显示，在酒精摄入量低于 55g/天的人群中，酒精摄入量与总髋部的粗平均 BMD 呈正相关。相比之下，酒精摄入量为 55g/天或更多的人群中，酒精摄入量与 BMD 呈负相关。本项针对日本老年男性的大规模研究表明，尽管每日酒精摄入量<55g 与 BMD 呈正相关，但每日酒精摄入量≥55g 与 BMD 呈负相关。
