吸烟对老年男性骨密度和骨代谢的影响：岩手县骨质疏松男性风险（FORMEN）研究。
Impact of smoking on bone mineral density and bone metabolism in elderly men: the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study.
机构信息
Department of Public Health, Kinki University School of Medicine, 377-2, Oono-higasi, Osaka-sayama, Osaka, 589-8511, Japan.
出版信息
Osteoporos Int. 2011 Jan;22(1):133-41. doi: 10.1007/s00198-010-1238-x. Epub 2010 Apr 10.
UNLABELLED
Our cross-sectional analysis of 1,576 men aged ≥65 years examined smoking effects on bone status. Number of smoking years was associated with decreased bone mineral density (BMD), after adjusting for age, height, weight, and number of cigarettes smoked daily. Smoking did not affect biochemical marker serum values for bone turnover.
INTRODUCTION
The impact of smoking on bone status in men has not been conclusively established. We examined how smoking and its cessation influence bone status and metabolism in men.
METHODS
We analyzed 1,576 men among a baseline survey of Japanese men aged ≥65 years, the Fujiwara-kyo Osteoporosis Risk in Men study, conducted during 2007-2008.
RESULTS
Lumbar spine (LS) BMD values among never, former, and current smokers were 1.045 ± 0.194, 1.030 ± 0.189, and 1.001 ± 0.182 g/cm(2) (P = 0.005), respectively, while total hip (TH) BMD values were 0.888 ± 0.120, 0.885 ± 0.127, and 0.870 ± 0.124 (P = 0.078), respectively. The significant trend for LS BMD remained after adjusting for the covariates; age, height, weight, physical activity, milk consumption, and drinking habit (P = 0.036). Among never and ever (current and former) smokers, LS and TH BMD decreased with the number of pack years or the number of smoking years, respectively, adjusted for those covariates. Among ever smokers, LS and TH BMD decreased with the number of smoking years after adjusting for age, height, weight, and number of cigarettes smoked daily. Smoking did not reveal significant effect for serum osteocalcin or tartrate resistant acid phosphatase isoenzyme 5b.
CONCLUSION
The impact of smoking on bone status is mainly associated with the number of smoking years in elderly men.
目的
本研究通过对 1576 名年龄≥65 岁男性的横断面分析，探讨吸烟对骨量的影响。在调整年龄、身高、体重和每日吸烟量后，吸烟年限与骨密度降低相关。吸烟对骨转换的生化标志物血清值没有影响。
引言
吸烟对男性骨量的影响尚未得到明确证实。我们研究了吸烟及其戒断对男性骨量和代谢的影响。
方法
我们分析了日本年龄≥65 岁男性基线调查，即富士山-京骨质疏松风险男性研究（2007-2008 年进行）中的 1576 名男性。
结果
从不吸烟者、前吸烟者和现吸烟者的腰椎（LS）骨密度值分别为 1.045±0.194、1.030±0.189 和 1.001±0.182g/cm2（P=0.005），而总髋（TH）骨密度值分别为 0.888±0.120、0.885±0.127 和 0.870±0.124（P=0.078）。在调整协变量（年龄、身高、体重、体力活动、牛奶摄入量和饮酒习惯）后，LS 骨密度值的显著趋势仍然存在（P=0.036）。在从不吸烟者和（当前和以前）吸烟者中，LS 和 TH 骨密度随吸烟年限或吸烟年数的增加而降低，在调整了这些协变量后，这一趋势仍然存在。在吸烟者中，在调整年龄、身高、体重和每日吸烟量后，LS 和 TH 骨密度随吸烟年限的增加而降低。吸烟对血清骨钙素或抗酒石酸酸性磷酸酶 5b 的影响没有显著差异。
结论
吸烟对老年男性骨量的影响主要与吸烟年限有关。
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