Research Centre for Toxic Compounds in the Environment (RECETOX), Faculty of Science, Masaryk University, Kamenice 126/3, Brno, CZ-62500, Czech Republic.
Ecotoxicol Environ Saf. 2011 Sep;74(6):1727-33. doi: 10.1016/j.ecoenv.2011.04.013. Epub 2011 Apr 29.
The aim of this study was to compare the toxic effects of selected two- and three-ringed PAHs (naphthalene, phenanthrene, and anthracene) and their N-heterocyclic analogs with one (quinoline, acridine, and phenanthridine) or two (quinoxaline, phenazine, and 1,10-phenanthroline) nitrogen atoms on the survival and reproduction of Enchytraeus crypticus in artificial soil. Toxicity of compounds was recalculated to soil pore-water concentrations using the data of chemical analyses of 0.01 M CaCl(2) extracts of spiked soils. When toxicity was based on molar concentrations in pore water (μmol/L), it significantly increased with increasing K(ow) value. This relationship indicates nonpolar narcosis as the general toxicity mechanism of the tested compounds. In addition, significant correlation between the toxicity of PACs and their ionization potential has been identified by multidimensional QSAR models.
本研究旨在比较选定的双环和三环多环芳烃（萘、菲和蒽）及其 N-杂环类似物与一个（喹啉、吖啶和菲啶）或两个（喹喔啉、吩嗪和 1,10-菲咯啉）氮原子对在人工土壤中生存和繁殖的真涡虫的毒性影响。化合物的毒性使用污染土壤的 0.01 M CaCl(2)提取物的化学分析数据重新计算为土壤孔隙水中的浓度。当毒性基于孔隙水中的摩尔浓度（μmol/L）时，它随着 Kow 值的增加而显著增加。这种关系表明非极性麻醉作用是测试化合物的一般毒性机制。此外，通过多维 QSAR 模型确定了 PAC 毒性与其电离势之间的显著相关性。
