脂联素和抵抗素在胃肠道疾病中的意义。

The implication of adiponectin and resistin in gastrointestinal diseases.

机构信息

Department of Gastroenterology, University of Thessaly, University Hospital of Larissa, School of Medicine, Greece.

出版信息

Cytokine Growth Factor Rev. 2011 Apr;22(2):109-19. doi: 10.1016/j.cytogfr.2011.04.002. Epub 2011 Apr 29.

DOI:10.1016/j.cytogfr.2011.04.002

Abstract

Adiponectin and resistin, members of the adipokine family, are multi-task hormones involved in several disorders, including those of the alimentary tract. In the present review, eligible studies focusing on the role of adiponectin and resistin in gastrointestinal diseases are manifested together and classified according to anatomic criteria. In addition, similarities and common patterns have been recognized, ultimately revealing an inverse association: the down-regulation of adiponectin and up-regulation of resistin - both in vitro and in vivo - in gastrointestinal disorders, irrespective of their diverse nature - inflammatory, autoimmune or malignant - or anatomic position - esophageal, gastric, of the small intestine, colonic. Finally, a potential role for both adipokines in alimentary tract-related carcinogenesis has been identified, possibly representing a missing link between obesity and cancer.

摘要

脂联素和抵抗素是脂肪因子家族的成员，是涉及多种疾病的多功能激素，包括胃肠道疾病。在本综述中，符合条件的研究集中在脂联素和抵抗素在胃肠道疾病中的作用，并根据解剖学标准进行分类。此外，已经认识到相似性和共同模式，最终揭示了一种相反的关联：在胃肠道疾病中，脂联素的下调和抵抗素的上调——无论是在体外还是体内——无论其性质（炎症、自身免疫或恶性）或解剖位置（食管、胃、小肠、结肠）如何。最后，已经确定了这两种脂肪因子在与消化道相关的致癌作用中的潜在作用，这可能代表肥胖和癌症之间缺失的联系。