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Pharmacological inhibition of HDAC6 attenuates endothelial barrier dysfunction induced by thrombin.
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Selective HDAC6 inhibition prevents TNF-α-induced lung endothelial cell barrier disruption and endotoxin-induced pulmonary edema.
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Histone deacetylase inhibitors prevent pulmonary endothelial hyperpermeability and acute lung injury by regulating heat shock protein 90 function.
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MeCP2 deficiency is associated with reduced levels of tubulin acetylation and can be restored using HDAC6 inhibitors.
J Mol Med (Berl). 2015 Jan;93(1):63-72. doi: 10.1007/s00109-014-1202-x. Epub 2014 Sep 12.
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Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation.
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Zinc-Dependent Histone Deacetylases in Lung Endothelial Pathobiology.
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Selective HDAC6 inhibition protects against blood-brain barrier dysfunction after intracerebral hemorrhage.
CNS Neurosci Ther. 2024 Mar;30(3):e14429. doi: 10.1111/cns.14429. Epub 2023 Sep 4.
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Microtubules as Major Regulators of Endothelial Function: Implication for Lung Injury.
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Molecular Mechanisms of Vascular Damage During Lung Injury.
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Role of HDAC6 inhibition in sepsis-induced acute respiratory distress syndrome (Review).
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Inhibition of Class IIa HDACs improves endothelial barrier function in endotoxin-induced acute lung injury.
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Nafamostat mesylate attenuates the pathophysiologic sequelae of neurovascular ischemia.
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Histone deacetylases in vascular permeability and remodeling associated with acute lung injury.
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Requirement of a novel splicing variant of human histone deacetylase 6 for TGF-beta1-mediated gene activation.
Biochem Biophys Res Commun. 2010 Feb 19;392(4):608-13. doi: 10.1016/j.bbrc.2010.01.091. Epub 2010 Jan 25.
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Acetylation goes global: the emergence of acetylation biology.
Sci Signal. 2009 Nov 17;2(97):pe76. doi: 10.1126/scisignal.297pe76.
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Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Science. 2009 Aug 14;325(5942):834-40. doi: 10.1126/science.1175371. Epub 2009 Jul 16.
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The role of cytoskeleton in the regulation of vascular endothelial barrier function.
Microvasc Res. 2008 Nov;76(3):202-7. doi: 10.1016/j.mvr.2008.06.003. Epub 2008 Jun 28.
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Requirement of HDAC6 for transforming growth factor-beta1-induced epithelial-mesenchymal transition.
J Biol Chem. 2008 Jul 25;283(30):21065-73. doi: 10.1074/jbc.M802786200. Epub 2008 May 21.
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Suppression of endotoxin-induced inflammation by taxol.
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Activation of proMMP-2 and Src by HHV8 vGPCR in human pulmonary arterial endothelial cells.
J Mol Cell Cardiol. 2007 Mar;42(3):517-25. doi: 10.1016/j.yjmcc.2006.08.004. Epub 2006 Dec 26.
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GEF-H1 is involved in agonist-induced human pulmonary endothelial barrier dysfunction.
Am J Physiol Lung Cell Mol Physiol. 2006 Mar;290(3):L540-8. doi: 10.1152/ajplung.00259.2005. Epub 2005 Oct 28.

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