Martínez-Peñuela A, Iglesias M E, Mercado M R, Martínez-Peñuela J M
Servicio de Anatomía Patológica, Hospital de Navarra, Pamplona, España.
Actas Dermosifiliogr. 2011 Dec;102(10):817-20. doi: 10.1016/j.ad.2011.02.011. Epub 2011 Apr 30.
Dermal melanocytosis refers to congenital or acquired lesions characterized by the presence of dendritic cells derived from melanocytes that migrate from the neural crest to the epidermis. The nevus of Ito develops in the territory supplied by the acromioclavicular nerve. Malignant transformation in dermal melanocytosis is extremely rare, with only isolated case reports; only 2 cases of malignant transformation of a nevus of Ito have been reported. We report a very rare case that is the third to be described in the literature. The patient was a 24-year-old man who presented with a subcutaneous nodule that had developed in the anterolateral region of the thorax over the previous 8 months. The nodule was located beneath a faint blue-gray macule with poorly defined borders. Biopsy of the nodule revealed malignant melanoma; biopsies of the adjacent skin lesion showed a diffuse proliferation of scattered melanocytes in a collagen stroma in the reticular dermis. A diagnosis of malignant transformation of a nevus of Ito was made after other possibilities were ruled out.
皮肤黑素细胞增多症是指先天性或后天性病变，其特征是存在源自神经嵴迁移至表皮的黑素细胞的树突状细胞。伊藤痣发生于肩锁神经所支配的区域。皮肤黑素细胞增多症的恶变极为罕见，仅有个别病例报告；伊藤痣恶变的报告仅有2例。我们报告1例非常罕见的病例，这是文献中描述的第3例。患者为一名24岁男性，其胸部前外侧区域在过去8个月内出现了一个皮下结节。该结节位于边界不清的淡蓝灰色斑下方。结节活检显示为恶性黑色素瘤；相邻皮肤病变活检显示网状真皮层胶原基质中散在黑素细胞弥漫性增生。排除其他可能性后，诊断为伊藤痣恶变。
