Department of Dermatology, University of Fukui, Fukui, Japan.
J Dermatol. 2010 Feb;37(2):167-70. doi: 10.1111/j.1346-8138.2009.00780.x.
63-year-old man presented with a dome-shaped, black nodule on his right forehead, where hairs were preserved. The black surface tone measured 7 mm in diameter and spread irregularly from the periphery of the nodule. He had been conscious of the preceding, black macule for approximately 50 years. A snap shot of the patient in adolescence showed a tiny, black macule, which was a few millimeters in diameter. Histological examination demonstrated irregular proliferation of melanoma cells from the epidermis to the dermis. Partially, there were well-circumscribed, oval nests composed of nevus cells in the acanthotic epidermis and follicles. Nevus cells were also seen in the dermal component, presenting a burnt-out appearance. In this case, the small final size, the preserved hairs and the snap shot suggested a preceding, acquired melanocytic nevus. Malignant melanoma could arise from acquired melanocytic nevus.
一位 63 岁男性，右侧额头上有一个呈圆顶状的黑色结节，其上保留有毛发。黑色表面直径约 7 毫米，从结节边缘不规则扩散。他大约 50 年前就注意到了之前的黑色斑点。患者青春期的快照显示一个直径几毫米的小黑斑。组织学检查显示黑色素瘤细胞从表皮不规则增生至真皮。部分棘层肥厚的表皮和毛囊中可见界限清楚的椭圆形巢状黑色素细胞。真皮成分中也可见到黑色素细胞，呈烧毁样外观。在这种情况下，小结节的大小、保留的毛发和快照提示存在先前获得性的黑色素细胞痣。恶性黑色素瘤可能起源于获得性黑色素细胞痣。
