GC-MS 法测定人尿中左旋咪唑使用后的氨苯恶啉
Determination of aminorex in human urine samples by GC-MS after use of levamisole.
机构信息
Division of Forensic Toxicology, Department of Anatomy, Histology and Legal Medicine, University of Florence, Italy.
出版信息
J Pharm Biomed Anal. 2011 Jul 15;55(5):1186-9. doi: 10.1016/j.jpba.2011.03.039. Epub 2011 Apr 6.
The Drug Enforcement Administration (DEA) reports that as of October 2010, 79% of all cocaine seized in the United States contained levamisole. The equine conversion of levamisole to aminorex has been demonstrated. However, the metabolic fate of levamisole in humans is unknown. Nevertheless, as aminorex is amphetamine-like and hallucinogenic, it may be used as an adulterant to increase the effects of cocaine. We report here the results of in vivo studies demonstrating for the first time that not only equine, but also canine and human metabolism all result in aminorex formation. Levamisole and aminorex were extracted from real urine samples by liquid-liquid extraction and identified and quantified by GC-MS (identification by 3 ions per substance, LLOQ at 0.15ng/ml for both).
美国缉毒局（DEA）报告称，截至 2010 年 10 月，在美国缉获的所有可卡因中，有 79%含有左旋咪唑。已经证明左旋咪唑在马体内转化为氨基比林。然而，左旋咪唑在人体内的代谢途径尚不清楚。尽管如此，由于氨基比林具有安非他命样和致幻作用，它可能被用作掺杂物来增加可卡因的效果。我们在这里报告的体内研究结果首次表明，不仅马，而且犬和人代谢都会导致氨基比林的形成。左旋咪唑和氨基比林通过液-液萃取从真实尿液样本中提取，并通过 GC-MS 进行鉴定和定量（每种物质鉴定 3 个离子，LLOQ 均为 0.15ng/ml）。
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