一例左旋咪唑诱发的粒细胞缺乏症

A Case of Levamisole-Induced Agranulocytosis.

作者信息

Kassim Thamer, Chintalacheruvu Lakshmi, Bhatty Osman, Selim Mohammad, Diab Osama, Nayfeh Ali, Manikkam Umakanthan Jayadev, Gbadamosi-Akindele Maryam

机构信息

Department of Internal Medicine, Creighton University, Omaha, NE, USA.

University of Nebraska Medical Center, Omaha, NE, USA.

出版信息

Case Rep Hematol. 2018 Feb 11;2018:7341835. doi: 10.1155/2018/7341835. eCollection 2018.

DOI:10.1155/2018/7341835

PMID:29607229

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5828115/

Abstract

A sixty-eight-year-old male with a past medical history of recurrent cocaine use presented to the emergency department with recurrent diarrhea and was found to have a white blood cell (WBC) count of 1.9 × 10/L with agranulocytosis (absolute neutrophil count (ANC) of 95 cell/mm). At admission, the patient disclosed that he used cocaine earlier during the day, and a urine drug screen tested positive for this. On hospital day one, the patient was found to have a fever with a maximum temperature of 313.6 K. After ruling out other causes and noting the quick turnaround of his neutropenia after four days of cocaine abstinence, the patient's neutropenia was attributed to levamisole-adulterated cocaine.

摘要

一名68岁男性，有反复使用可卡因的病史，因反复腹泻就诊于急诊科，白细胞（WBC）计数为1.9×10/L，伴有粒细胞缺乏症（绝对中性粒细胞计数（ANC）为95个细胞/mm）。入院时，患者透露当天早些时候使用过可卡因，尿液药物筛查呈阳性。在住院第一天，发现患者发热，最高体温为313.6K。在排除其他原因并注意到在戒除可卡因四天后他的中性粒细胞减少迅速好转后，患者的中性粒细胞减少归因于掺有左旋咪唑的可卡因。