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一例左旋咪唑诱发的粒细胞缺乏症

A Case of Levamisole-Induced Agranulocytosis.

作者信息

Kassim Thamer, Chintalacheruvu Lakshmi, Bhatty Osman, Selim Mohammad, Diab Osama, Nayfeh Ali, Manikkam Umakanthan Jayadev, Gbadamosi-Akindele Maryam

机构信息

Department of Internal Medicine, Creighton University, Omaha, NE, USA.

University of Nebraska Medical Center, Omaha, NE, USA.

出版信息

Case Rep Hematol. 2018 Feb 11;2018:7341835. doi: 10.1155/2018/7341835. eCollection 2018.

DOI:10.1155/2018/7341835
PMID:29607229
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5828115/
Abstract

A sixty-eight-year-old male with a past medical history of recurrent cocaine use presented to the emergency department with recurrent diarrhea and was found to have a white blood cell (WBC) count of 1.9 × 10/L with agranulocytosis (absolute neutrophil count (ANC) of 95 cell/mm). At admission, the patient disclosed that he used cocaine earlier during the day, and a urine drug screen tested positive for this. On hospital day one, the patient was found to have a fever with a maximum temperature of 313.6 K. After ruling out other causes and noting the quick turnaround of his neutropenia after four days of cocaine abstinence, the patient's neutropenia was attributed to levamisole-adulterated cocaine.

摘要

一名68岁男性,有反复使用可卡因的病史,因反复腹泻就诊于急诊科,白细胞(WBC)计数为1.9×10/L,伴有粒细胞缺乏症(绝对中性粒细胞计数(ANC)为95个细胞/mm)。入院时,患者透露当天早些时候使用过可卡因,尿液药物筛查呈阳性。在住院第一天,发现患者发热,最高体温为313.6K。在排除其他原因并注意到在戒除可卡因四天后他的中性粒细胞减少迅速好转后,患者的中性粒细胞减少归因于掺有左旋咪唑的可卡因。

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本文引用的文献

1
Adverse effects of levamisole in cocaine users: a review and risk assessment.左旋咪唑在可卡因使用者中的不良反应:综述和风险评估。
Arch Toxicol. 2017 Jun;91(6):2303-2313. doi: 10.1007/s00204-017-1947-4. Epub 2017 Mar 17.
2
Levamisole-adulterated cocaine: a case of retiform purpura, cutaneous necrosis and neutropenia.左旋咪唑掺杂可卡因:一例网状紫癜、皮肤坏死和中性粒细胞减少症
BMJ Case Rep. 2015 Jul 22;2015:bcr2015211768. doi: 10.1136/bcr-2015-211768.
3
Genetic determinants of cocaine-associated agranulocytosis.可卡因相关性粒细胞缺乏症的遗传决定因素。
BMC Res Notes. 2015 Jun 13;8:240. doi: 10.1186/s13104-015-1219-4.
4
Levamisole-induced leukocytoclastic vasculitis and neutropenia in a patient with cocaine use: an extensive case with necrosis of skin, soft tissue, and cartilage.患者使用可卡因致左旋咪唑诱导的白细胞碎裂性血管炎和中性粒细胞减少症:伴有皮肤、软组织和软骨坏死的广泛病例。
Addict Sci Clin Pract. 2012 Sep 24;7(1):19. doi: 10.1186/1940-0640-7-19.
5
Levamisole in cocaine: unexpected news from an old acquaintance.可卡因中的左旋咪唑:旧相识带来的意外消息。
Clin Toxicol (Phila). 2012 Apr;50(4):231-41. doi: 10.3109/15563650.2012.665455.
6
Agranulocytosis and other consequences due to use of illicit cocaine contaminated with levamisole.因使用混有左旋咪唑的非法可卡因而导致的粒细胞缺乏症和其他后果。
Curr Opin Hematol. 2012 Jan;19(1):27-31. doi: 10.1097/MOH.0b013e32834da9ef.
7
Determination of aminorex in human urine samples by GC-MS after use of levamisole.GC-MS 法测定人尿中左旋咪唑使用后的氨苯恶啉
J Pharm Biomed Anal. 2011 Jul 15;55(5):1186-9. doi: 10.1016/j.jpba.2011.03.039. Epub 2011 Apr 6.
8
Agranulocytosis after consumption of cocaine adulterated with levamisole.食用掺有左旋咪唑的可卡因后发生的粒细胞缺乏症。
Ann Intern Med. 2009 Feb 17;150(4):287-9. doi: 10.7326/0003-4819-150-4-200902170-00102. Epub 2009 Jan 19.
9
Systematic review: agranulocytosis induced by nonchemotherapy drugs.系统评价:非化疗药物所致粒细胞缺乏症
Ann Intern Med. 2007 May 1;146(9):657-65. doi: 10.7326/0003-4819-146-9-200705010-00009.