Department of Infectious Diseases, Heidelberg University School of Medicine, 69120 Heidelberg, Germany.
Trends Mol Med. 2011 Sep;17(9):527-36. doi: 10.1016/j.molmed.2011.05.008. Epub 2011 Jul 6.
The worldwide burden of malaria can be substantially reduced using existing public health interventions. However, elimination of Plasmodium will require fundamentally different approaches. Novel experimental attenuation strategies for active immunization using knockout strains have recently stimulated renewed interest in whole-parasite vaccine approaches. Preventive drug administration during transmission of wild-type sporozoites is a complementary strategy for eliciting protective immune responses. These whole-cell immunization strategies are based on one fundamental principle: inducing protection by blocking parasite conversion from the clinically silent liver phase to the pathogenic intra-erythrocytic replication cycle. Here, we review the basis, evidence and targets for whole-cell-based vaccination strategies against the liver stage bottleneck in Plasmodium infections and discuss preclinical and clinical research opportunities.
利用现有的公共卫生干预措施，可以大大减轻疟疾的全球负担。然而，消除疟原虫将需要从根本上采取不同的方法。最近，使用基因敲除株进行主动免疫的新型实验减毒策略激发了人们对全寄生虫疫苗方法的重新兴趣。在传播野生型子孢子期间进行预防性药物给药是诱导保护性免疫反应的一种补充策略。这些全细胞免疫策略基于一个基本原则：通过阻止寄生虫从临床无症状的肝期向致病性红内复制周期的转化来诱导保护。在这里，我们回顾了基于全细胞的针对疟原虫感染肝期瓶颈的疫苗接种策略的基础、证据和靶点，并讨论了临床前和临床研究机会。
