Department of Oncology, Azienda Ospedaliera 'Ospedali Riuniti Marche Nord', Presidio San Salvatore, Pesaro.
Department of Medical Oncology, 2 Universitaria, Azienda Ospedaliero-Universitaria Pisana, Pisa.
Ann Oncol. 2012 Jan;23(1):135-141. doi: 10.1093/annonc/mdr062. Epub 2011 Apr 29.
Previous studies investigating the prognostic role of mucinous histology of colorectal cancer produced conflicting results. This retrospective analysis was carried out in order to explore whether mucinous adenocarcinoma (MC) is associated with a comparatively worse prognosis than that of nonmucinous adenocarcinoma (NMC) for patients undergoing curative resection for stage II and III colon cancer.
This study involved 1025 unselected patients who underwent curative surgery for sporadic colon cancer and follow-up procedures at six different oncology departments.
MCs accounted for 17.4% (n=178) of tumours. Patients with MC had 5- and 8-year overall survival rates of 78.6% and 68.8%, respectively, compared with 72.3% and 63.8%, respectively, for patients with nonmucinous tumours. Multivariate analysis using the Cox proportional hazards model showed that the clinically significant prognostic factors were stage of disease and adjuvant chemotherapy. No statistically significant interaction between mucinous histology and adjuvant chemotherapy was found.
For patients with stage II and III colon cancer who underwent curative surgery, mucinous histology has no significant correlation with prognosis compared with NMC. This retrospective analysis suggests a comparable benefit from adjuvant chemotherapy for MC compared with NMC.
先前研究结直肠癌黏液组织学的预后作用得出了相互矛盾的结果。本回顾性分析旨在探讨在接受 II 期和 III 期结肠癌根治性切除术的患者中，黏液性腺癌（MC）是否比非黏液性腺癌（NMC）预后更差。
本研究纳入了 1025 例未选择的接受散发性结肠癌根治性手术和在六个不同肿瘤学部门进行随访的患者。
MC 占肿瘤的 17.4%（n=178）。MC 患者的 5 年和 8 年总生存率分别为 78.6%和 68.8%，而非 MC 患者的 5 年和 8 年总生存率分别为 72.3%和 63.8%。使用 Cox 比例风险模型的多变量分析显示，疾病分期和辅助化疗是具有临床意义的预后因素。未发现黏液组织学和辅助化疗之间存在统计学显著的交互作用。
对于接受根治性手术的 II 期和 III 期结肠癌患者，与 NMC 相比，MC 的组织学无显著相关性。本回顾性分析表明，MC 患者从辅助化疗中获益与 NMC 相似。
