麻风病中的肾功能障碍：巴西923例患者的历史队列研究。
Renal dysfunction in leprosy: a historical cohort of 923 patients in Brazil.
作者信息
Daher Elizabeth F, Silva Geraldo B, Cezar Lia C, Lima Rafael S A, Gurjão Natacha H, Mota Rosa M S, Abreu Krasnalhia Lívia S, Rocha Natália A, Oliveira Michelle J C, Libório Alexandre B
机构信息
Department of Internal Medicine, School of Medicine, Walter Cantídio University Hospital, Federal University of Ceará, Fortaleza, Ceará, Brazil.
出版信息
Trop Doct. 2011 Jul;41(3):148-50. doi: 10.1258/td.2011.100436. Epub 2011 Apr 30.
We investigated the factors associated with renal dysfunction in leprosy patients from Brazil. We report on a historical cohort of leprosy patients followed in two hospitals in Fortaleza City in northeastern Brazil. The factors associated with renal dysfunction were investigated. A total of 923 patients were included, with a mean age of 41.5 ± 19.1 years, and 53.3% were male. Renal dysfunction was found in 35 cases (3.8%). Proteinuria was found in 4.8% of cases, haematuria in 6.8% and leukocyturia in 10.4%. Factors associated with renal dysfunction by multivariate analysis were: reaction episode (odds ratio [OR] = 3.9, P = 0.03), multibacillary classification (OR = 3.5, P = 0.02) and advanced age (OR = 1.04, P = 0.01). Four patients (0.4%) died. Leprosy is associated with renal dysfunction, especially in older patients and those presenting with reaction episode and multibacillary classification.
我们调查了巴西麻风病患者肾功能不全的相关因素。我们报告了在巴西东北部福塔莱萨市两家医院随访的一组麻风病患者历史队列。对与肾功能不全相关的因素进行了调查。共纳入923例患者，平均年龄为41.5±19.1岁，53.3%为男性。发现35例（3.8%）存在肾功能不全。4.8%的病例有蛋白尿，6.8%有血尿，10.4%有白细胞尿。多因素分析显示与肾功能不全相关的因素为：反应期（比值比[OR]=3.9，P=0.03）、多菌型分类（OR=3.5，P=0.02）和高龄（OR=1.04，P=0.01）。4例患者（0.4%）死亡。麻风病与肾功能不全相关，尤其是在老年患者以及出现反应期和多菌型分类的患者中。
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