Parente Yuri de Deus Mont'alverne, Castro Amanda Lopes de, Araújo Flávio Bezerra de, Teixeira André Costa, Lima Ítalo Criszostomo, Daher Elizabeth De Francesco
Hospital Geral Dr. Waldemar Alcântara, Departamento de Clínica Médica, Fortaleza, CE, Brasil.
Hospital Geral Dr. Waldemar Alcântara, Fortaleza, CE, Brasil.
J Bras Nefrol. 2019 Jan-Mar;41(1):152-156. doi: 10.1590/2175-8239-jbn-2018-0056. Epub 2018 Aug 23.
Rapidly progressive glomerulonephritis (RPGN) is a renal disease with an extensive differential diagnosis. This paper reports the case of a 55-year-old female patient diagnosed with Hansen's disease with acute progressive renal impairment after developing lower limb pyoderma. The association between Hansen's and kidney disease has been well documented, with glomerulonephritis (GN) ranked as the most common form of renal involvement. Post-infectious glomerulonephritis (PIGN) in adults has been associated with a number of pathogens occurring in diverse sites. The patient described in this case report had RPGN and biopsy findings suggestive of PIGN with C3 and IgA detected on immunofluorescence and kidney injury secondary to recent infection by Staphylococcus, a well-documented manifestation of renal impairment in patients with Hansen's disease.
急进性肾小球肾炎(RPGN)是一种需要进行广泛鉴别诊断的肾脏疾病。本文报告了一例55岁女性患者的病例,该患者在出现下肢脓疱病后被诊断为汉森病并伴有急性进行性肾功能损害。汉森病与肾脏疾病之间的关联已有充分记录,肾小球肾炎(GN)是肾脏受累最常见的形式。成人感染后肾小球肾炎(PIGN)与多种部位出现的多种病原体有关。本病例报告中描述的患者患有RPGN,活检结果提示为PIGN,免疫荧光检测发现C3和IgA,肾脏损伤继发于近期金黄色葡萄球菌感染,这是汉森病患者肾功能损害的一种已充分记录的表现。