3型呼肠孤病毒与β-肾上腺素能受体的拮抗剂结构域结合。
Reovirus type 3 binds to antagonist domains of the beta-adrenergic receptor.
作者信息
Donta S T, Shanley J D
机构信息
Department of Medicine, University of Connecticut School of Medicine, Farmington 06032.
出版信息
J Virol. 1990 Feb;64(2):639-41. doi: 10.1128/JVI.64.2.639-641.1990.
Abstract
Reovirus type 3 interfered with the binding of beta-adrenergic antagonist ligands to receptors on Y1 adrenal, C6 glioma, and mouse L cells. This inhibition of beta-adrenergic binding was dose related. Reovirus did not interfere with dopaminergic binding or isoproterenol-induced activation of adenylate cyclase. In addition, reovirus infected Y1 cells, which bind beta-adrenergic antagonist ligands but lack agonist-induced activity. These results suggest that reovirus infection is initiated by binding to antagonist (nonfunctional) domains of the adrenergic receptor complex.
摘要
3型呼肠孤病毒干扰β-肾上腺素能拮抗剂配体与Y1肾上腺细胞、C6胶质瘤细胞和小鼠L细胞上受体的结合。这种对β-肾上腺素能结合的抑制与剂量相关。呼肠孤病毒不干扰多巴胺能结合或异丙肾上腺素诱导的腺苷酸环化酶激活。此外，呼肠孤病毒感染Y1细胞，Y1细胞能结合β-肾上腺素能拮抗剂配体但缺乏激动剂诱导的活性。这些结果表明，呼肠孤病毒感染是通过与肾上腺素能受体复合物的拮抗剂（无功能）结构域结合而启动的。
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