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关于姑息性氧疗作用的最新进展

Update on the role of palliative oxygen.

机构信息

Centre for Cardiovascular and Chronic Care, University of Technology Sydney, Sydney, Australia.

出版信息

Curr Opin Support Palliat Care. 2011 Jun;5(2):87-91. doi: 10.1097/SPC.0b013e3283463cd3.

Abstract

PURPOSE OF REVIEW

Breathlessness remains a frequent and burdensome symptom for individuals with life-limiting symptoms in both malignant and nonmalignant settings. As oxygen therapy is frequently given as part of the management of breathlessness and is associated with costs, treatment burden and potential dangers, it is timely to review the efficacy and appropriateness of palliative oxygen therapy.

RECENT FINDINGS

Despite the widespread use of oxygen therapy in clinical and community settings, data supporting this approach is sparse. The benefits of long-term oxygen therapy for severely hypoxaemic people with chronic obstructive pulmonary disease are proven; however, mounting evidence suggests that oxygen does not confer additional benefit over medical air for the relief of refractory breathlessness in people with mild or absent hypoxaemia.

SUMMARY

On the basis of the findings of this review, the routine use of palliative oxygen therapy without detailed assessment of pathogenesis and reversibility of symptoms cannot be justified. Promoting self-management strategies, such as cool airflow across the face, exercise and psychological support for patients and carers, should be considered before defaulting to oxygen therapy. If palliative oxygen therapy is considered for individuals with transient or mild hypoxaemia, a therapeutic trial should be conducted with clinical review after 3 days to assess the net clinical benefit and patient preference.

摘要

目的综述

在恶性和非恶性疾病终末期患者中,呼吸困难仍然是一种常见且负担沉重的症状。由于氧气疗法作为呼吸困难管理的一部分经常被使用,且与成本、治疗负担和潜在危险相关,因此及时审查姑息性氧疗的疗效和适宜性是适时的。

最新发现

尽管氧气疗法在临床和社区环境中广泛使用,但支持这种方法的数据很少。长期氧疗对严重低氧血症的慢性阻塞性肺疾病患者的疗效已得到证实;然而,越来越多的证据表明,对于轻度或无低氧血症的难治性呼吸困难患者,与医用空气相比,氧气并不能带来额外的益处。

总结

基于本综述的结果,如果没有详细评估症状的发病机制和可逆性,不能证明常规使用姑息性氧疗是合理的。在默认使用氧气疗法之前,应考虑促进自我管理策略,如用凉爽的空气吹拂面部、运动和对患者和护理人员的心理支持。如果考虑对有短暂或轻度低氧血症的患者使用姑息性氧疗,应在 3 天后进行临床评估,以评估净临床获益和患者偏好。

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