Deretzi Georgia, Kountouras Jannis, Zavos Christos, Giartza-Taxidou Evangelia, Koutlas Evangelos, Kiriazopoulou Eleonora, Tsiptsios Iakovos
Neurology Department, Papageorgiou General Regional Hospital, Thessaloniki, Macedonia, Greece.
Neurologist. 2011 May;17(3):172-5. doi: 10.1097/NRL.0b013e3182173552.
Multiple sclerosis (MS), idiopathic dilated cardiomyopathy (DCM), and diabetes mellitus-1 (DM-1) are polygenic autoimmune diseases with a pivotal autoimmune component affecting young adults. They share a number of characteristics, thereby suggesting common underlying pathways or mechanisms. Typically, the aforementioned diseases are organ-specific autoimmune disorders of unknown etiology, but with strong evidence of tissue-destructive activity of the humoral and/or cellular immune system in the end-organ tissues affected (ie, the myelin components in MS, the myocytes of myocardium in DCM, and the insulin-secreting β islets in DM-1).
We herein describe a 35-year-old white Greek man who presented with coexisting MS, DCM, and DM-1 diagnosed over a period of 7 years. The patient was successfully treated and is asymptomatic until present time.
The clustering of these 3 autoimmune diseases in our patient supports the concept of an immune-mediated damage in these diseases, an important aspect for an effective therapeutic choice by neurologists. However, the immunopathogenetic association between MS and other autoimmune remains speculative, thereby warranting further clarification.
多发性硬化症（MS）、特发性扩张型心肌病（DCM）和1型糖尿病（DM - 1）是多基因自身免疫性疾病，其关键的自身免疫成分会影响年轻人。它们具有许多共同特征，因此提示存在共同的潜在途径或机制。通常，上述疾病是病因不明的器官特异性自身免疫性疾病，但有强有力的证据表明，在受影响的终末器官组织（即MS中的髓鞘成分、DCM中的心肌细胞以及DM - 1中的胰岛素分泌β细胞）中，体液和/或细胞免疫系统具有组织破坏活性。
我们在此描述一名35岁的希腊白人男性，他在7年时间里先后被诊断出患有MS、DCM和DM - 1。该患者已成功接受治疗，至今无症状。
我们的患者中这三种自身免疫性疾病的聚集支持了这些疾病中存在免疫介导损伤的概念，这是神经科医生进行有效治疗选择的一个重要方面。然而，MS与其他自身免疫性疾病之间的免疫发病机制关联仍属推测，因此需要进一步阐明。
