University of California, Department of Medicine, San Francisco VA Medical Center, San Francisco, CA, USA
Curr Opin Rheumatol. 2011 Jul;23(4):389-95. doi: 10.1097/BOR.0b013e3283474dbe.
To present an updated summary of the relationship between inflammation and localized and generalized bone loss in the rheumatic diseases.
In addition to the well established role of inflammatory cytokines in promoting enhanced osteoclast function and bone loss, recent work has discovered the cytokine milieu may also inhibit osteoblast function and bone repair. The WNT and bone morphogenetic protein pathways provide molecular links between inflammation and altered bone homeostasis in chronic inflammatory states. These pathways and others have been the targets of emerging therapies for the management of inflammatory bone loss.
Inflammation and bone loss are linked through a number of molecular pathways. Both of these processes need to be addressed when designing an effective treatment strategy for the rheumatic diseases.
介绍炎症与风湿性疾病中局部和全身骨丢失之间关系的最新研究进展。
除了炎症细胞因子在促进破骨细胞功能和骨丢失方面的作用已得到充分证实外，最近的研究还发现细胞因子微环境也可能抑制成骨细胞的功能和骨修复。WNT 和骨形态发生蛋白途径为慢性炎症状态下炎症和骨稳态改变之间提供了分子联系。这些途径和其他途径已成为治疗炎症性骨丢失的新兴疗法的靶点。
炎症和骨丢失通过多种分子途径相关联。在为风湿性疾病设计有效的治疗策略时，需要同时解决这两个问题。
