Division of Dermatology, Hospital University Marqués de Valdecilla, Santander, Spain.
Division of Dermatology, Hospital University Marqués de Valdecilla, Santander, Spain; Department of Medicine and Psychiatry, University of Cantabria, Santander, Spain; Valdecilla Biomedical Research Institute (IDIVAL), Santander, Spain.
Acta Derm Venereol. 2022 Nov 29;102:adv00825. doi: 10.2340/actadv.v102.3504.
Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the hair follicles. The aim of this case-control study was to assess whether HS is associated with disturbances in trabecular bone score, bone mineral density, bone remodelling markers, and calciotropic hormones. A total of 81 patients and 79 controls of similar age and sex were included. Demographic, anthropometric, laboratory data, trabecular bone score, bone mineral density, serum 25-hydroxyvitamin D (25OHD), serum amino-terminal pro-peptide of type 1 collagen (PINP), and C-terminal telopeptide of type 1 collagen (CTX) concentrations were assessed in both groups. Patients with HS had lower serum 25OHD levels than controls, and approximately 62% of them had vitamin D deficiency. Serum PINP was increased and CTX was decreased in patients with HS. Fully adjusted trabecular bone score values were lower in patients with HS compared with controls. Adjusted lumbar bone mineral density was similar in HS and controls, whilst total hip bone mineral density was lower in patients with HS. There were no statistical differences regarding disease severity in terms of 25OHD, serum turnover markers, bone mineral density, or trabecular bone score values. This study shows that patients with HS have lower trabecular bone score and total hip bone mineral density values than population-based controls. In addition, the prevalence of vitamin D deficiency is high in subjects with HS.
化脓性汗腺炎（HS）是一种毛囊慢性炎症性疾病。本病例对照研究旨在评估 HS 是否与骨小梁评分、骨密度、骨重塑标志物和钙调节激素紊乱有关。共纳入 81 例患者和 79 例年龄和性别相匹配的对照组。对两组患者的人口统计学、人体测量学、实验室数据、骨小梁评分、骨密度、血清 25-羟维生素 D（25OHD）、血清 1 型胶原氨基端前肽（PINP）和 1 型胶原 C 端肽（CTX）浓度进行评估。与对照组相比，HS 患者的血清 25OHD 水平较低，约 62%的患者存在维生素 D 缺乏。HS 患者的血清 PINP 升高，CTX 降低。与对照组相比，HS 患者的全髋关节骨小梁评分值明显较低。HS 组和对照组的腰椎骨密度调整后相似，而 HS 患者的总髋骨密度较低。在维生素 D、血清转换标志物、骨密度或骨小梁评分值方面，两组患者的疾病严重程度没有统计学差异。本研究表明，与基于人群的对照组相比，HS 患者的骨小梁评分和总髋骨密度值较低。此外，HS 患者维生素 D 缺乏的患病率较高。
