阿尔茨海默病中的氟代脱氧葡萄糖和淀粉样蛋白正电子发射断层扫描：整体是否大于部分之和？
FDG- and amyloid-PET in Alzheimer's disease: is the whole greater than the sum of the parts?
作者信息
Mosconi L, McHugh P F
机构信息
Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA.
出版信息
Q J Nucl Med Mol Imaging. 2011 Jun;55(3):250-64.
Abstract
The development of prevention therapies for Alzheimer's disease (AD) would greatly benefit from biomarkers that are sensitive to subtle brain changes occurring prior to the onset of clinical symptoms, when the potential for preservation of function is at the greatest. In vivo brain imaging is a promising tool for the early detection of AD through visualization of abnormalities in brain structure, function and histopathology. Currently, positron emission tomography (PET) imaging with amyloid-beta (Aβ) tracers and 2-[(18)F]fluoro-2-Deoxy-D-glucose (FDG) is largely utilized in the diagnosis of AD. This paper reviews brain Aβ- and FDG-PET studies in AD patients as well as in non-demented individuals at risk for AD. We then discuss the potential of combining symptoms-sensitive FDG-PET measures with pathology-specific Aβ-PET to improve the early detection of AD.
摘要
阿尔茨海默病（AD）预防疗法的发展将极大地受益于生物标志物，这些生物标志物对临床症状出现之前发生的细微脑变化敏感，而此时功能保存的潜力最大。体内脑成像通过可视化脑结构、功能和组织病理学异常，是早期检测AD的一种有前途的工具。目前，使用淀粉样β蛋白（Aβ）示踪剂和2-[(18)F]氟-2-脱氧-D-葡萄糖（FDG）的正电子发射断层扫描（PET）成像在很大程度上用于AD的诊断。本文综述了AD患者以及有AD风险的非痴呆个体的脑Aβ和FDG-PET研究。然后，我们讨论了将症状敏感的FDG-PET测量与病理特异性Aβ-PET相结合以改善AD早期检测的潜力。
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