载脂蛋白 E4 及痴呆母亲病史对海马体萎缩的影响。
Effects of ApoE4 and maternal history of dementia on hippocampal atrophy.
机构信息
Pritzker School of Medicine, University of Chicago, Chicago, IL, USA.
出版信息
Neurobiol Aging. 2012 May;33(5):856-66. doi: 10.1016/j.neurobiolaging.2010.07.020. Epub 2010 Sep 15.
Abstract
We applied an automated hippocampal segmentation technique based on adaptive boosting (AdaBoost) to the 1.5 T magnetic resonance imaging (MRI) baseline and 1-year follow-up data of 243 subjects with mild cognitive impairment (MCI), 96 with Alzheimer's disease (AD), and 145 normal controls (NC) scanned as part of the Alzheimer's Disease Neuroimaging Initiative (ADNI). MCI subjects with positive maternal history of dementia had smaller hippocampal volumes at baseline and at follow-up, and greater 12-month atrophy rates than subjects with negative maternal history. Three-dimensional maps and volumetric multiple regression analyses demonstrated a significant effect of positive maternal history of dementia on hippocampal atrophy in MCI and AD after controlling for age, ApoE4 genotype, and paternal history of dementia, respectively. ApoE4 showed an independent effect on hippocampal atrophy in MCI and AD and in the pooled sample.
摘要
我们将一种基于自适应增强（AdaBoost）的自动海马分割技术应用于 243 名轻度认知障碍（MCI）患者、96 名阿尔茨海默病（AD）患者和 145 名正常对照者的 1.5 T 磁共振成像（MRI）基线和 1 年随访数据，这些数据均为阿尔茨海默病神经影像学倡议（ADNI）的一部分。有阳性家族史的 MCI 患者在基线和随访时的海马体积较小，12 个月的萎缩率也高于阴性家族史的患者。三维图谱和容积多重回归分析表明，在控制年龄、ApoE4 基因型和父系痴呆史后，阳性家族史对 MCI 和 AD 中的海马萎缩有显著影响。ApoE4 对 MCI 和 AD 以及混合样本中的海马萎缩有独立影响。
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