Department of Psychiatry, St Alexius Hospital, 3933 South Broadway, St Louis, MO 63118, USA.
Clin Geriatr Med. 2010 Feb;26(1):113-23. doi: 10.1016/j.cger.2009.12.001.
The term dementia refers to memory impairment and loss of other intellectual abilities, which interfere with normal daily activities. Alzheimer disease is a type of dementia that accounts for 50% to 70% of dementia cases. Although the precise reason behind dementia is unknown, there are several risk factors that increase the risk for the development for dementia and several protective factors that may protect against the development of dementia. This article reviews potential risk factors and protective factors for the development of dementia, and in particular Alzheimer disease, and discusses the challenges in developing a dementia risk index.
痴呆症是指记忆障碍和其他智力能力的丧失，这些会干扰正常的日常活动。阿尔茨海默病是一种痴呆症，占痴呆症病例的 50%至 70%。尽管痴呆症的确切原因尚不清楚，但有几个风险因素会增加发展为痴呆症的风险，还有几个保护因素可能预防痴呆症的发展。本文综述了痴呆症（特别是阿尔茨海默病）发展的潜在风险因素和保护因素，并讨论了开发痴呆症风险指数的挑战。
