• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

冯晨在转化医学与临床影像学方面的工作。

Feng Chen's work on translational and clinical imaging.

作者信息

Chen Feng

机构信息

Feng Chen, Section of Radiology, Department of Medical Diagnostic Sciences, Faculty of Medicine, University of Leuven, 3000 Leuven, Belgium.

出版信息

World J Radiol. 2011 Apr 28;3(4):120-4. doi: 10.4329/wjr.v3.i4.120.

DOI:10.4329/wjr.v3.i4.120
PMID:21532873
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3084436/
Abstract

Dr. Feng Chen is a chief medical doctor and the vice chairman of the Department of Radiology in Zhong Da Hospital at Southeast University, Nanjing, China and a senior researcher in the Department of Radiology at the Catholic University of Leuven, Belgium. His main areas of interest are translational imaging research including stroke, tumor angiogenesis, assessment of therapeutic response in solid tumors, and magnetic resonance contrast media. Dr. Feng Chen has published 44 scientific papers in peer-reviewed international journals. He and his colleagues have developed an imaging platform which includes animal models, animal preparations and multiparametric magnetic resonance imaging (MRI) protocols for translational animal imaging research using clinical machines. His MRI findings on rodent stroke are considered to "serve as a model for future laboratory investigations of treatment of acute stroke and unify the approaches developed for clinical studies". He and his colleagues have introduced a novel liver tumor model in rodents, in which a series of studies concerning the antitumor activity of vascular disrupting agents have been successively conducted and assessed by in vivo MRI, especially by diffusion weighted imaging as an imaging biomarker. His goal is to provide valuable references for clinical practice and to contribute to the translation of animal imaging research into patient applications.

摘要

陈峰博士是中国南京东南大学附属中大医院放射科主任医师及副主任,也是比利时鲁汶天主教大学放射科高级研究员。他主要的研究领域是转化成像研究,包括中风、肿瘤血管生成、实体瘤治疗反应评估以及磁共振造影剂。陈峰博士已在同行评审的国际期刊上发表了44篇科学论文。他和同事们开发了一个成像平台,该平台包括动物模型、动物准备以及使用临床设备进行转化动物成像研究的多参数磁共振成像(MRI)方案。他在啮齿动物中风方面的MRI研究结果被认为“可作为未来急性中风治疗实验室研究的模型,并统一为临床研究开发的方法”。他和同事们在啮齿动物中引入了一种新型肝肿瘤模型,在该模型中,已相继开展了一系列关于血管破坏剂抗肿瘤活性的研究,并通过体内MRI进行评估,尤其是将扩散加权成像作为成像生物标志物。他的目标是为临床实践提供有价值的参考,并为将动物成像研究转化为患者应用做出贡献。

相似文献

1
Feng Chen's work on translational and clinical imaging.冯晨在转化医学与临床影像学方面的工作。
World J Radiol. 2011 Apr 28;3(4):120-4. doi: 10.4329/wjr.v3.i4.120.
2
Abass Alavi: A giant in Nuclear Medicine turns 80 and is still going strong!阿巴斯·阿拉维:核医学领域的一位巨擘迎来80岁生日,依然精力充沛!
Hell J Nucl Med. 2018 Jan-Apr;21(1):85-87. doi: 10.1967/s002449910713. Epub 2018 Mar 20.
3
Contribution of late professor T. C. Tung to the experimental embryology of Amphioxus. In memory of the 20th anniversary of Professor T. C. Tung's death.已故童第周教授对文昌鱼实验胚胎学的贡献。纪念童第周教授逝世20周年。
Dev Growth Differ. 1999 Oct;41(5):503-22. doi: 10.1046/j.1440-169x.1999.00464.x.
4
From the History of the Croatian Dermatovenereological Society - The Croatian Medical Association and an Overview of Important Information Regarding the Journal Acta Dermatovenerologica Croatica.克罗地亚皮肤性病学会史——克罗地亚医学协会及《克罗地亚皮肤性病学学报》重要信息概述
Acta Dermatovenerol Croat. 2018 Dec;26(4):344-348.
5
Remembering Judah Moses Folkma.缅怀犹大·摩西·福克马。
Int J Biol Markers. 2008 Jan-Mar;23(1):63. doi: 10.1177/172460080802300111.
6
Predicting Clinical Efficacy of Vascular Disrupting Agents in Rodent Models of Primary and Secondary Liver Cancers: An Overview with Imaging-Histopathology Correlation.预测血管破坏剂在原发性和继发性肝癌啮齿动物模型中的临床疗效:影像学与组织病理学相关性概述
Diagnostics (Basel). 2020 Jan 31;10(2):78. doi: 10.3390/diagnostics10020078.
7
In memoriam: Jean Blancou, DVM, 1936-2010. World authority on rabies, historian and former Director General of the World Organisation for Animal Health (Office International des Épizooties: OIE).纪念:让·布兰库,兽医学博士,1936 - 2010年。狂犬病领域的世界权威、历史学家,曾任世界动物卫生组织(国际兽疫局:OIE)总干事。
Vet Ital. 2011 Jan-Mar;47(1):105-6.
8
Development and characterization of a rat brain metastatic tumor model by multiparametric magnetic resonance imaging and histomorphology.通过多参数磁共振成像和组织形态学方法建立大鼠脑转移瘤模型的建立和特点描述。
Clin Exp Metastasis. 2022 Jun;39(3):479-493. doi: 10.1007/s10585-022-10155-w. Epub 2022 Feb 26.
9
Trial design and reporting standards for intra-arterial cerebral thrombolysis for acute ischemic stroke.急性缺血性脑卒中动脉内脑溶栓的试验设计与报告标准。
Stroke. 2003 Aug;34(8):e109-37. doi: 10.1161/01.STR.0000082721.62796.09. Epub 2003 Jul 17.
10
Cancer models-multiparametric applications of clinical MRI in rodent hepatic tumor model.癌症模型——临床MRI在啮齿动物肝肿瘤模型中的多参数应用
Methods Mol Biol. 2011;771:489-507. doi: 10.1007/978-1-61779-219-9_26.

本文引用的文献

1
Cancer models-multiparametric applications of clinical MRI in rodent hepatic tumor model.癌症模型——临床MRI在啮齿动物肝肿瘤模型中的多参数应用
Methods Mol Biol. 2011;771:489-507. doi: 10.1007/978-1-61779-219-9_26.
2
Morphological, functional and metabolic imaging biomarkers: assessment of vascular-disrupting effect on rodent liver tumours.形态学、功能和代谢成像生物标志物:评估对啮齿类动物肝肿瘤的血管破坏作用。
Eur Radiol. 2010 Aug;20(8):2013-26. doi: 10.1007/s00330-010-1743-5. Epub 2010 Feb 25.
3
Dynamic contrast-enhanced and diffusion-weighted MRI for early detection of tumoral changes in single-dose and fractionated radiotherapy: evaluation in a rat rhabdomyosarcoma model.单次剂量和分割放疗中动态对比增强和弥散加权 MRI 早期检测肿瘤变化:在大鼠横纹肌肉瘤模型中的评估。
Eur Radiol. 2009 Nov;19(11):2663-71. doi: 10.1007/s00330-009-1451-1. Epub 2009 Jun 6.
4
Diffusion-weighted MRI of hepatic tumor in rats: comparison between in vivo and postmortem imaging acquisitions.大鼠肝脏肿瘤的扩散加权磁共振成像:活体与死后成像采集的比较
J Magn Reson Imaging. 2009 Mar;29(3):621-8. doi: 10.1002/jmri.21675.
5
Rat model of reperfused partial liver infarction: characterization with multiparametric magnetic resonance imaging, microangiography, and histomorphology.再灌注性部分肝梗死大鼠模型:多参数磁共振成像、微血管造影及组织形态学特征
Acta Radiol. 2009 Apr;50(3):276-87. doi: 10.1080/02841850802647021.
6
Treatment of rodent liver tumor with combretastatin a4 phosphate: noninvasive therapeutic evaluation using multiparametric magnetic resonance imaging in correlation with microangiography and histology.磷酸藤黄酸A4治疗啮齿动物肝肿瘤:使用多参数磁共振成像与微血管造影和组织学相关的无创治疗评估
Invest Radiol. 2009 Jan;44(1):44-53. doi: 10.1097/RLI.0b013e31818e5ace.
7
Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth.骨髓来源的循环内皮前体细胞对血管内皮没有贡献,且肿瘤生长不需要它们。
Proc Natl Acad Sci U S A. 2008 May 6;105(18):6620-5. doi: 10.1073/pnas.0710516105. Epub 2008 Apr 28.
8
Murine liver implantation of radiation-induced fibrosarcoma: characterization with MR imaging, microangiography and histopathology.辐射诱导的纤维肉瘤在小鼠肝脏中的植入:磁共振成像、微血管造影和组织病理学特征分析
Eur Radiol. 2008 Jul;18(7):1422-30. doi: 10.1007/s00330-008-0904-2. Epub 2008 Mar 15.
9
Comparing two methods for assessment of perfusion-diffusion mismatch in a rodent model of ischaemic stroke: a pilot study.比较两种评估缺血性中风啮齿动物模型中灌注-扩散不匹配的方法:一项初步研究。
Br J Radiol. 2008 Mar;81(963):192-8. doi: 10.1259/bjr/70940134. Epub 2008 Jan 7.
10
Hypericin as a marker for determination of tissue viability after intratumoral ethanol injection in a murine liver tumor model.金丝桃素作为小鼠肝肿瘤模型中瘤内注射乙醇后组织活力测定的标志物。
Acad Radiol. 2008 Jan;15(1):107-13. doi: 10.1016/j.acra.2007.08.008.