持续性变应性鼻炎患者鼻腔金黄色葡萄球菌携带的免疫作用

Immunological role of nasal staphylococcus aureus carriage in patients with persistent allergic rhinitis.

作者信息

Refaat Maged Mohamed, Ahmed Tarek Mansour, Ashour Zeinab Ahmed, Atia Mohamed Yousif

机构信息

Internal Medicine department, Ain Shams University, Cairo, Egypt;

出版信息

Pan Afr Med J. 2008 Oct 30;1:3.

PMID:21532892

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2984262/

Abstract

Nasal carriage of staphylococcus aureus (S.aureus) exerts immunomodulatory effect in patients with atopic dermatitis and it may contribute to airway inflammation and allergic response in patients with allergic rhinitis. We Aim to investigate the frequency of nasal S.aureus carriage in patients with persistent allergic rhinitis and its possible influence on their symptoms and immune markers. We chosed 20 non smoker patients with house dust mite (HDM) allergy causing allergic rhinitis and 20 non smoker healthy subjects matched for age and sex. For all subjects rhinoscopy was done, skin prick test, nasal culture for S.aureus, nasal interleukin 4,nasal total IgE, serum total IgE and serum specific IgE(SSIgE) for HDM. Nasal S.aureus was detected in 16/20 patients (80%) and 5/20 (25%) in healthy subjects with highly significant statistical difference p<0.01. Correlation of nasal staph.aureus count and different systemic and local immune markers revealed highly significant positive correlation between nasal S.aureus count and serum total IgE (r = 0.78, p<0.01) and significant positive correlation with SSIgE (HDM) (r = 0.53, p<0.05), nasal total IgE (r = 0.39, p<0.05) and nasal IL-4 (r = 0.55, p<0.05). Nasal staph.aureus actively modulated the immune reaction in persistent allergic rhinitis patients by promoting local IgE production, so we recommend early detection and treatment of S.aureus carriage in patients.

摘要

金黄色葡萄球菌（S.aureus）的鼻腔定植对特应性皮炎患者具有免疫调节作用，并且可能导致过敏性鼻炎患者的气道炎症和过敏反应。我们旨在调查持续性过敏性鼻炎患者鼻腔金黄色葡萄球菌定植的频率及其对患者症状和免疫标志物的可能影响。我们选择了20名因屋尘螨（HDM）过敏引起过敏性鼻炎的不吸烟患者以及20名年龄和性别相匹配的不吸烟健康受试者。对所有受试者进行了鼻内镜检查、皮肤点刺试验、金黄色葡萄球菌鼻腔培养、鼻腔白细胞介素4、鼻腔总IgE、血清总IgE和针对HDM的血清特异性IgE（SSIgE）检测。在16/20例患者（80%）中检测到鼻腔金黄色葡萄球菌，而在健康受试者中为5/20例（25%），差异具有高度统计学意义，p<0.01。鼻腔金黄色葡萄球菌计数与不同的全身和局部免疫标志物之间的相关性显示，鼻腔金黄色葡萄球菌计数与血清总IgE之间存在高度显著的正相关（r = 0.78，p<0.01），与SSIgE（HDM）存在显著正相关（r = 0.53，p<0.05），与鼻腔总IgE（r = 0.39，p<0.05）和鼻腔白细胞介素4（r = 0.55，p<0.05）存在显著正相关。鼻腔金黄色葡萄球菌通过促进局部IgE产生，积极调节持续性过敏性鼻炎患者的免疫反应，因此我们建议对患者的金黄色葡萄球菌定植进行早期检测和治疗。