Parrett M, Harris R, Joarder F, Ross M, Clausen K, Robertson F
OHIO STATE UNIV,DEPT MED MICROBIOL & IMMUNOL,COLL MED,COLUMBUS,OH 43210. OHIO STATE UNIV,COLL MED,DEPT PATHOL,COLUMBUS,OH 43210. OHIO STATE UNIV,COLL MED,SCH PUBL HLTH,COLUMBUS,OH 43210. OHIO STATE UNIV,COLL MED,CTR COMPREHENS CANC,COLUMBUS,OH 43210.
Int J Oncol. 1997 Mar;10(3):503-7. doi: 10.3892/ijo.10.3.503.
Expression of the inducible isoform of the cyclooxygenase gene (PGHS-2, COX-2) which codes for the enzyme that catalyzes formation of prostaglandins, was detected in 13/13 human breast tumors of high grade but not in samples of normal breast tissue. There was a statistically significant linear association between COX-2 gene expression and high (>50%) tumor cell density (p<0.01), with COX-2 protein localized to tumor cells. These results indicate that COX-2 gene expression may be useful as a molecular biomarker for human breast tumors and may also predict sensitivity to treatment with nonsteroidal anti-inflammatory drugs.
编码催化前列腺素形成的酶的环氧化酶基因（PGHS - 2，COX - 2）的诱导型异构体在13例高级别人类乳腺肿瘤中均有表达，但在正常乳腺组织样本中未检测到。COX - 2基因表达与高（>50%）肿瘤细胞密度之间存在统计学上显著的线性关联（p<0.01），COX - 2蛋白定位于肿瘤细胞。这些结果表明，COX - 2基因表达可能作为人类乳腺肿瘤的分子生物标志物，也可能预测对非甾体抗炎药治疗的敏感性。
