Harvard Medical School, Boston, MA 02115, USA.
Curr Urol Rep. 2011 Aug;12(4):297-303. doi: 10.1007/s11934-011-0196-y.
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a chronic pain syndrome identified by the presence of noninfectious pelvic or perineal pain lasting longer than 3 months. Current diagnoses and treatments for the syndrome solely depend on and target symptoms, respectively. Thus far, the mechanistic disturbances responsible for the pathogenesis of CP/CPPS have remained largely elusive and treatments, and therefore, continue to be ineffective. To move toward successful management and treatment of CP/CPPS, it is necessary to elicit the underlying biological mechanisms responsible for the syndrome. Therefore, a phenotyping system that is able to bridge the gap between current symptom-based diagnosis and future mechanistic approaches to diagnosis and treatment is needed. In this article, we examine current CP/CPPS phenotyping systems, analyze their utility, and make suggestions for changes in clinical approaches to the syndrome that would both promulgate a mechanistic understanding and advance treatment approaches.
慢性前列腺炎/慢性骨盆疼痛综合征（CP/CPPS）是一种以非传染性骨盆或会阴疼痛持续超过 3 个月为特征的慢性疼痛综合征。目前对该综合征的诊断和治疗仅分别依赖于症状和针对症状。迄今为止，导致 CP/CPPS 发病机制的机制紊乱在很大程度上仍难以捉摸，因此治疗方法仍然无效。为了成功管理和治疗 CP/CPPS，有必要引出负责该综合征的潜在生物学机制。因此，需要一种表型系统来弥合当前基于症状的诊断与未来针对诊断和治疗的机制方法之间的差距。在本文中，我们检查了当前的 CP/CPPS 表型系统，分析了它们的效用，并对临床方法的改变提出了建议，这些建议既可以促进对机制的理解，也可以推进治疗方法。
