Department of Medicine, Section of Genetic Medicine, University of Chicago, Chicago, Illinois 60637, USA.
J Toxicol Environ Health B Crit Rev. 2011;14(1-4):246-66. doi: 10.1080/10937404.2011.556052.
Asbestos and related fibers are associated with a number of adverse health effects, including malignant mesothelioma (MM), an aggressive cancer that generally develops in the surface serosal cells of the pleural, pericardial, and peritoneal cavities. Although approximately 80% of individuals with MM are exposed to asbestos, fewer than 5% of asbestos workers develop MM. In addition to asbestos, other mineralogical, environmental, genetic, and possibly viral factors might contribute to MM susceptibility. Given this complex etiology of MM, understanding susceptibility to MM needs to be a priority for investigators in order to reduce exposure of those most at risk to known environmental carcinogens. In this review, the current body of literature related to fiber-associated disease susceptibility including age, sex, nutrition, genetics, asbestos, and other mineral exposure is addressed with a focus on MM, and critical areas for further study are recommended.
石棉和相关纤维与许多不良健康影响有关，包括恶性间皮瘤（MM），这是一种侵袭性癌症，通常发生在胸膜、心包和腹膜腔的表面浆膜细胞中。尽管约 80%的 MM 患者接触过石棉，但不到 5%的石棉工人会患上 MM。除了石棉，其他矿物学、环境、遗传和可能的病毒因素也可能导致 MM 的易感性。鉴于 MM 的这种复杂病因，了解 MM 的易感性需要成为研究人员的优先事项，以减少那些最易受到已知环境致癌物暴露的人群的暴露。在这篇综述中，我们讨论了与纤维相关的疾病易感性的现有文献，包括年龄、性别、营养、遗传、石棉和其他矿物质暴露，重点是 MM，并推荐了进一步研究的关键领域。
