Department of Biology, College of Arts & Sciences, Barry University, Miami Shores, FL, USA.
Cell Prolif. 2011 Jun;44(3):205-11. doi: 10.1111/j.1365-2184.2011.00753.x.
Cell cycle progression is controlled by both extracellular and intracellular signalling molecules. It has been generally believed that cdc2/CDK1 only control G(2)-M transition in mammalian and many other higher eukaryotic cells. Accumulating evidence shows that cdc2 not only promotes G(2)-M transition but is also capable of regulating G(1) progress and G(1)-S transition via association with multiple interphase cyclins; cdc2 activity can be inhibited by p21 and p27, two traditional G(1) CDK inhibitors. In addition, cdc2-cyclin B controls pronuclear union in interphase fertilized eggs. These data suggest that cdc2 may be a pluripotent CDK. Although mechanisms responsible for the multiple functions of cdc2 remain to be further investigated, interactions of cdc2 with pRb and with several important transcription factors may provide a clue to the pluripotent role of cdc2.
细胞周期的进程受到细胞外和细胞内信号分子的控制。人们普遍认为，cdc2/CDK1 仅在哺乳动物和许多其他高等真核细胞中控制 G(2)-M 转换。越来越多的证据表明，cdc2 不仅促进 G(2)-M 转换，还能够通过与多种间期细胞周期蛋白的结合来调节 G(1)进程和 G(1)-S 转换；cdc2 活性可以被 p21 和 p27 抑制，这两种传统的 G(1)CDK 抑制剂。此外，cdc2-细胞周期蛋白 B 控制间期受精卵的原核融合。这些数据表明 cdc2 可能是一种多能 CDK。尽管 cdc2 多种功能的机制仍有待进一步研究，但 cdc2 与 pRb 和几个重要转录因子的相互作用可能为 cdc2 的多能作用提供线索。
