在“组学”时代的真菌致病性基因。
Fungal pathogenicity genes in the age of 'omics'.
机构信息
School of Botany, University of Melbourne, Vic. 3010, Australia.
出版信息
Mol Plant Pathol. 2011 Jun;12(5):507-14. doi: 10.1111/j.1364-3703.2010.00680.x. Epub 2010 Dec 6.
Abstract
The identification of the fungal genes essential for disease underpins the development of disease control strategies. Improved technologies for gene identification and functional analyses, as well as a plethora of sequenced fungal genomes, have led to the characterization of hundreds of genes, denoted as pathogenicity genes, which are required by fungi to cause disease. We describe recent technologies applied to characterize the fungal genes involved in disease and focus on some genes that are likely to attract continuing research activity.
摘要
鉴定对疾病至关重要的真菌基因是制定疾病控制策略的基础。基因鉴定和功能分析技术的改进，以及大量测序的真菌基因组，已经导致了数百个基因的特征描述，这些基因被称为致病性基因，是真菌引起疾病所必需的。我们描述了最近应用于鉴定与疾病有关的真菌基因的技术，并重点介绍了一些可能吸引持续研究活动的基因。
相似文献
1
Fungal pathogenicity genes in the age of 'omics'.在“组学”时代的真菌致病性基因。
Mol Plant Pathol. 2011 Jun;12(5):507-14. doi: 10.1111/j.1364-3703.2010.00680.x. Epub 2010 Dec 6.
2
The dawn of fungal pathogen genomics.真菌病原体基因组学的开端。
Annu Rev Phytopathol. 2006;44:337-66. doi: 10.1146/annurev.phyto.44.070505.143412.
3
(Post-)genomics approaches in fungal research.真菌研究中的（后）基因组学方法。
Brief Funct Genomics. 2014 Nov;13(6):424-39. doi: 10.1093/bfgp/elu028. Epub 2014 Jul 17.
4
Functional analysis of pathogenicity genes in a genomics world.基因组时代致病基因的功能分析
Curr Opin Microbiol. 2001 Aug;4(4):387-92. doi: 10.1016/s1369-5274(00)00222-8.
5
Fungal genomics and pathogenicity.真菌基因组学与致病性。
Curr Opin Plant Biol. 2001 Aug;4(4):315-21. doi: 10.1016/s1369-5266(00)00179-5.
6
Smut fungi as a stratagem to characterize rust effectors: opportunities and challenges.菌核作为特征锈菌效应物的策略：机遇与挑战。
World J Microbiol Biotechnol. 2020 Sep 14;36(10):150. doi: 10.1007/s11274-020-02927-x.
7
Genomic adaptation: a fungal perspective.基因组适应：真菌视角
Nat Rev Microbiol. 2008 Aug;6(8):572-3. doi: 10.1038/nrmicro1964.
8
9
Methods for Genomic Characterization and Maintenance of Anaerobic Fungi.厌氧真菌的基因组特征分析与维持方法
Methods Mol Biol. 2018;1775:53-67. doi: 10.1007/978-1-4939-7804-5_5.
10
Fungal biology: compiling genomes and exploiting them.真菌生物学：基因组编纂与应用
New Phytol. 2014 Jul;203(2):359-361. doi: 10.1111/nph.12891.
引用本文的文献
1
Unlocking the potential of Metschnikowia pulcherrima: a dive into the genomic and safety characterization of four plant-associated strains.挖掘美丽梅奇酵母的潜力：深入研究四株与植物相关菌株的基因组及安全性特征
Appl Microbiol Biotechnol. 2025 May 29;109(1):128. doi: 10.1007/s00253-025-13515-0.
2
Diplodia tip blight pathogen's virulence empowered through host switch.葡萄座腔菌梢枯病菌通过宿主转换增强毒力。
Front Fungal Biol. 2022 Jul 28;3:939007. doi: 10.3389/ffunb.2022.939007. eCollection 2022.
3
Higher Virulence of Isolates on Vines of cv. Cabernet Sauvignon Associated with 10-Year-Old Wood Compared to Young Tissue.与幼嫩组织相比，分离株对赤霞珠葡萄品种10年生木质藤本的毒力更强。
Plants (Basel). 2023 Aug 18;12(16):2984. doi: 10.3390/plants12162984.
4
The Bursaphelenchus xylophilus effector BxML1 targets the cyclophilin protein (CyP) to promote parasitism and virulence in pine.松材线虫效应因子 BxML1 靶向亲环蛋白（CyP）以促进松树的寄生和毒力。
BMC Plant Biol. 2022 Apr 27;22(1):216. doi: 10.1186/s12870-022-03567-z.
5
Identifying candidate Aspergillus pathogenicity factors by annotation frequency.通过注释频率鉴定曲霉属致病性因素候选物。
BMC Microbiol. 2020 Nov 11;20(1):342. doi: 10.1186/s12866-020-02031-y.
6
Induction of esterase activity during the degradation of high concentrations of the contaminant di(2-ethylhexyl) phthalate by under liquid fermentation conditions.在液体发酵条件下，[具体微生物名称]对高浓度污染物邻苯二甲酸二（2-乙基己基）酯进行降解过程中酯酶活性的诱导。
3 Biotech. 2020 Nov;10(11):488. doi: 10.1007/s13205-020-02476-y. Epub 2020 Oct 26.
7
Pathogenomics and Management of Diseases in Plants.植物病害的病原基因组学与管理
Pathogens. 2020 May 1;9(5):340. doi: 10.3390/pathogens9050340.
8
PHI-Nets: A Network Resource for Ascomycete Fungal Pathogens to Annotate and Identify Putative Virulence Interacting Proteins and siRNA Targets.PHI网络：一种用于子囊菌真菌病原体注释和鉴定假定毒力相互作用蛋白及小干扰RNA靶点的网络资源。
Front Microbiol. 2019 Dec 6;10:2721. doi: 10.3389/fmicb.2019.02721. eCollection 2019.
9
Pan-Parastagonospora Comparative Genome Analysis-Effector Prediction and Genome Evolution.泛帕拉塔戈诺孢子菌比较基因组分析——效应子预测与基因组进化。
Genome Biol Evol. 2018 Sep 1;10(9):2443-2457. doi: 10.1093/gbe/evy192.
10
Comparative genomics of Cryptococcus neoformans var. grubii associated with meningitis in HIV infected and uninfected patients in Vietnam.越南HIV感染和未感染患者中与脑膜炎相关的新型隐球菌格鲁比变种的比较基因组学
PLoS Negl Trop Dis. 2017 Jun 14;11(6):e0005628. doi: 10.1371/journal.pntd.0005628. eCollection 2017 Jun.
本文引用的文献
1
Conserved fungal LysM effector Ecp6 prevents chitin-triggered immunity in plants.真菌保守性 LysM 效应因子 Ecp6 抑制植物的几丁质触发免疫。
Science. 2010 Aug 20;329(5994):953-5. doi: 10.1126/science.1190859.
2
New developments in pathogenicity and virulence of necrotrophs.坏死营养型病原菌的致病性和毒力的新进展。
Curr Opin Plant Biol. 2010 Aug;13(4):415-9.
3
The use of FLP-mediated recombination for the functional analysis of an effector gene family in the biotrophic smut fungus Ustilago maydis.利用 FLP 介导的重组技术对生物寄生性黑粉菌玉米黑粉菌中的一个效应基因家族进行功能分析。
New Phytol. 2010 Sep;187(4):957-968. doi: 10.1111/j.1469-8137.2010.03413.x. Epub 2010 Jun 18.
4
Host-selective toxins, Ptr ToxA and Ptr ToxB, as necrotrophic effectors in the Pyrenophora tritici-repentis-wheat interaction.寄主选择性毒素 Ptr ToxA 和 Ptr ToxB 作为禾谷丝核菌-小麦互作中的坏死型效应因子。
New Phytol. 2010 Sep;187(4):911-9. doi: 10.1111/j.1469-8137.2010.03362.x. Epub 2010 Jul 14.
5
The autophagy genes ATG8 and ATG1 affect morphogenesis and pathogenicity in Ustilago maydis.自噬基因 ATG8 和 ATG1 影响玉米黑粉菌的形态发生和致病性。
Mol Plant Pathol. 2010 Jul;11(4):463-78. doi: 10.1111/j.1364-3703.2010.00620.x.
6
Pathogenesis, parasitism and mutualism in the trophic space of microbe-plant interactions.微生物-植物相互作用的营养空间中的发病机制、寄生和共生。
Trends Microbiol. 2010 Aug;18(8):365-73. doi: 10.1016/j.tim.2010.06.002. Epub 2010 Jul 1.
7
Proteomics of plant pathogenic fungi.植物病原真菌的蛋白质组学
J Biomed Biotechnol. 2010;2010:932527. doi: 10.1155/2010/932527. Epub 2010 May 27.
8
Pathogenicity genes of phytopathogenic fungi.植物病原真菌的致病性基因。
Mol Plant Pathol. 2001 Jul 1;2(4):241-55. doi: 10.1046/j.1464-6722.2001.00070.x.
9
The Fusarium graminearum MAP1 gene is essential for pathogenicity and development of perithecia.镰刀菌禾谷 MAP1 基因对其有性生殖体子囊壳的形成和致病性是必需的。
Mol Plant Pathol. 2003 Sep 1;4(5):347-59. doi: 10.1046/j.1364-3703.2003.00183.x.
10
The host-infecting fungal transcriptome.宿主感染真菌转录组。
FEMS Microbiol Lett. 2010 Jun;307(1):1-11. doi: 10.1111/j.1574-6968.2010.01961.x.
Zotero 插件