Department of Psychiatry, Duke University Medical Center, DHSP, Box 3837, Durham, 27710 NC, USA.
Psychiatr Clin North Am. 2011 Jun;34(2):423-35, ix. doi: 10.1016/j.psc.2011.02.001.
There is a large literature on the neuroanatomy of late-life depression that continues to grow with the discovery of novel structural imaging techniques along with innovative methods to analyze the images. Such advances have helped identify specific areas, characteristic lesions, and changes in the chemical composition in these regions that might be important in the pathophysiology of this complex disease. This article reviews relevant findings by each structural neuroimaging technique. When validated across many studies, such findings can serve as neuroanatomic markers that can help generate rational hypotheses for future studies to further understanding of geriatric depression.
有大量关于老年期抑郁症神经解剖学的文献，随着新的结构成像技术的发现以及分析图像的创新方法的出现，这一领域的文献还在不断增加。这些进展有助于确定特定区域、特征性病变以及这些区域化学成分的变化，这些可能对这种复杂疾病的病理生理学具有重要意义。本文综述了每种结构神经影像学技术的相关发现。当这些发现得到多项研究的验证时，它们可以作为神经解剖学标记物，有助于为未来的研究生成合理的假设，从而进一步了解老年期抑郁症。
