Gene Regulation Programme, Centre for Genomic Regulation (CRG) and UPF, Dr Aiguader 88, 08003-Barcelona, Spain.
Curr Opin Genet Dev. 2011 Aug;21(4):452-7. doi: 10.1016/j.gde.2011.04.006. Epub 2011 Apr 30.
Cytoplasmic polyadenylation is the process by which dormant, translationally inactive mRNAs become activated via the elongation of their poly(A) tails in the cytoplasm. This process is regulated by the conserved cytoplasmic polyadenylation element binding (CPEB) protein family. Recent studies have advanced our understanding of the molecular code that dictates the timing of CPEB-mediated poly(A) tail elongation and the extent of translational activation. In addition, evidence for CPEB-independent mechanisms has accumulated, and the breath of biological circumstances in which cytoplasmic polyadenylation plays a role has expanded. These observations underscore the versatility of CPEB as a translational regulator, and highlight the diversity of cytoplasmic polyadenylation mechanisms.
细胞质多聚腺苷酸化是一种通过在细胞质中延伸其多聚 A 尾巴来激活休眠的、翻译失活的 mRNAs 的过程。这个过程受到保守的细胞质多聚腺苷酸化元件结合（CPEB）蛋白家族的调控。最近的研究加深了我们对决定 CPEB 介导的多聚 A 尾巴延伸和翻译激活程度的分子密码的理解。此外，积累了 CPEB 非依赖性机制的证据，并且细胞质多聚腺苷酸化发挥作用的生物学情况的范围也扩大了。这些观察结果强调了 CPEB 作为翻译调节剂的多功能性，并突出了细胞质多聚腺苷酸化机制的多样性。
