CPEB介导的翻译调控：通向终点的一种方式。
Translational control by CPEB: a means to the end.
作者信息
Mendez R, Richter J D
机构信息
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.
出版信息
Nat Rev Mol Cell Biol. 2001 Jul;2(7):521-9. doi: 10.1038/35080081.
The regulated translation of messenger RNA is essential for cell-cycle progression, establishment of the body plan during early development, and modulation of key activities in the central nervous system. Cytoplasmic polyadenylation, which is one mechanism of controlling translation, is driven by CPEB--a highly conserved, sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element, and modulates translational repression and mRNA localization. What are the features and functions of this multifaceted protein?
信使核糖核酸（mRNA）的调控翻译对于细胞周期进程、早期发育过程中身体蓝图的建立以及中枢神经系统关键活动的调节至关重要。胞质聚腺苷酸化作为控制翻译的一种机制，由CPEB驱动，CPEB是一种高度保守的、序列特异性的RNA结合蛋白，它与胞质聚腺苷酸化元件结合，并调节翻译抑制和mRNA定位。这种多面蛋白的特征和功能是什么？
Zotero 插件