Lo J M, Pillai M R, John C S, Troutner D E
Department of Chemistry, University of Missouri, Columbia 65211.
Int J Rad Appl Instrum A. 1990;41(1):63-7. doi: 10.1016/0883-2889(90)90131-y.
The conjugation of a complex formed by reacting RhCl3 with cysteine to human serum albumin has been investigated. Approximately 50% of the rhodium (labeled with 105Rh) was converted to the complex. Conjugation of the complex to HSA via the ECDI method resulted in yields of approximately 40% of the total rhodium or approximately 80% of the Rh-cysteine complex. No conjugation was observed in the absence of the ECDI. At approximately equal molar concentrations of rhodium and HSA, an average of approximately 0.4 rhodium atoms per HSA molecule was achieved.
已对通过将RhCl₃与半胱氨酸反应形成的配合物与人血清白蛋白的共轭作用进行了研究。大约50%的铑（用¹⁰⁵Rh标记）转化为该配合物。通过ECDI方法将该配合物与HSA共轭，得到的产率约为铑总量的40%或Rh-半胱氨酸配合物的约80%。在没有ECDI的情况下未观察到共轭作用。在铑和HSA的摩尔浓度大致相等时，每个HSA分子平均约有0.4个铑原子。
