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小脑性共济失调中的睡眠障碍

Sleep disorders in cerebellar ataxias.

作者信息

Pedroso José L, Braga-Neto Pedro, Felício André C, Aquino Camila C H, Prado Lucila B Fernandes do, Prado Gilmar Fernandes do, Barsottini Orlando G P

机构信息

Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

出版信息

Arq Neuropsiquiatr. 2011 Apr;69(2A):253-7. doi: 10.1590/s0004-282x2011000200021.

Abstract

Cerebellar ataxias comprise a wide range of etiologies leading to central nervous system-related motor and non-motor symptoms. Recently, a large body of evidence has demonstrated a high frequency of non-motor manifestations in cerebellar ataxias, specially in autosomal dominant spinocerebellar ataxias (SCA). Among these non-motor dysfunctions, sleep disorders have been recognized, although still under or even misdiagnosed. In this review, we highlight the main sleep disorders related to cerebellar ataxias focusing on REM sleep behavior disorder (RBD), restless legs syndrome (RLS), periodic limb movement in sleep (PLMS), excessive daytime sleepiness (EDS), insomnia and sleep apnea.

摘要

小脑性共济失调包括多种病因,可导致与中枢神经系统相关的运动和非运动症状。最近,大量证据表明小脑性共济失调中,尤其是常染色体显性遗传性脊髓小脑共济失调(SCA),非运动表现的发生率很高。在这些非运动功能障碍中,睡眠障碍已得到认识,尽管仍未得到充分诊断甚至被误诊。在本综述中,我们重点介绍与小脑性共济失调相关的主要睡眠障碍,主要关注快速眼动睡眠行为障碍(RBD)、不宁腿综合征(RLS)、睡眠期周期性肢体运动(PLMS)、日间过度嗜睡(EDS)、失眠和睡眠呼吸暂停。

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