Jekpoo Sirivipa, Wongpakaran Nahathai, Wongpakaran Tinakon, Wantaneeyawong Chayasak, Wiriyacosol Punjaree, Methapatara Pised
Department of Psychiatry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Medicina (Kaunas). 2025 Jan 19;61(1):160. doi: 10.3390/medicina61010160.
Spinocerebellar ataxia (SCA) is a progressive neurodegenerative disease often accompanied by depression. This cross-sectional study investigated the prevalence of depression and the associated mental health factors in SCA patients. Eleven Thai SCA patients completed questionnaires assessing depression, anxiety, inner strengths, perceived social support, personality traits and perceived stress. Participants' average age was 50.27 years old. The prevalence of depression was 27.27%. Depression scores were positively correlated with OI-anxiety score ( = 0.887, 95%CI 0.586 to 0.968), perceived stress ( = 0781, 95%CI 0.305 to 0.936) and personality traits including aggression ( = 0.73, 95% CI 0.197 to 0.920), activity ( = 0.651, 95%CI 0.052 to 0.893) and neuroticism ( = 0.80, 95% CI 0.351 to 0.942). Conversely, depression negatively correlated with inner strengths ( = -0.70, 95%CI -0.910 to -0.139) and perceived social support, particularly from family ( = -0.88, 95%CI -0.966 to -0.564). These findings highlight the need for comprehensive mental health assessment and intervention in SCA patients. Strengthening inner strengths, promoting social support, and managing negative mental health factors may improve quality of life for patients with SCA.
脊髓小脑共济失调（SCA）是一种进行性神经退行性疾病，常伴有抑郁症。这项横断面研究调查了SCA患者中抑郁症的患病率及相关心理健康因素。11名泰国SCA患者完成了评估抑郁、焦虑、内在力量、感知到的社会支持、人格特质和感知压力的问卷。参与者的平均年龄为50.27岁。抑郁症的患病率为27.27%。抑郁评分与OI-焦虑评分呈正相关（=0.887，95%CI为0.586至0.968）、感知压力（=0.781，95%CI为0.305至0.936）以及包括攻击性（=0.73，95%CI为0.197至0.920）、活力（=0.651，95%CI为0.052至0.893）和神经质（=0.80，95%CI为0.351至0.942）在内的人格特质呈正相关。相反，抑郁与内在力量（= -0.70，95%CI为-0.910至-0.139）以及感知到的社会支持，尤其是来自家庭的支持呈负相关（= -0.88，95%CI为-0.966至-0.564）。这些发现凸显了对SCA患者进行全面心理健康评估和干预的必要性。增强内在力量、促进社会支持以及管理负面心理健康因素可能会改善SCA患者的生活质量。
