Paris Descartes University, Medicine Facility, APHP, Rheumatology B Department, Cochin Hospital, Paris, France.
Ann Rheum Dis. 2011 Jun;70(6):935-42. doi: 10.1136/ard.2010.142901.
A patient-derived composite measure of the impact of rheumatoid arthritis (RA), the rheumatoid arthritis impact of disease (RAID) score, takes into account pain, functional capacity, fatigue, physical and emotional wellbeing, quality of sleep and coping. The objectives were to finalise the RAID and examine its psychometric properties.
An international multicentre cross-sectional and longitudinal study of consecutive RA patients from 12 European countries was conducted to examine the psychometric properties of the different combinations of instruments that might be included within the RAID combinations scale (numeric rating scales (NRS) or various questionnaires). Construct validity was assessed cross-sectionally by Spearman correlation, reliability by intraclass correlation coefficient (ICC) in 50 stable patients, and sensitivity to change by standardised response means (SRM) in 88 patients whose treatment was intensified.
570 patients (79% women, mean ± SD age 56 ± 13 years, disease duration 12.5 ± 10.3 years, disease activity score (DAS28) 4.1 ± 1.6) participated in the validation study. NRS questions performed as well as longer combinations of questionnaires: the final RAID score is composed of seven NRS questions. The final RAID correlated strongly with patient global (R=0.76) and significantly also with other outcomes (DAS28 R=0.69, short form 36 physical -0.59 and mental -0.55, p<0.0001 for all). Reliability was high (ICC 0.90; 95% CI 0.84 to 0.94) and sensitivity to change was good (SRM 0.98 (0.96 to 1.00) compared with DAS28 SRM 1.06 (1.01 to 1.11)).
The RAID score is a patient-derived composite score assessing the seven most important domains of impact of RA. This score is now validated; sensitivity to change should be further examined in larger studies.
患者衍生的类风湿关节炎（RA）综合影响指标——类风湿关节炎疾病影响（RAID）评分，考虑了疼痛、功能能力、疲劳、身体和心理健康、睡眠质量和应对能力。本研究的目的是最终确定 RAID 评分，并检验其心理测量学特性。
本研究为国际性、多中心、横断和纵向研究，纳入了来自 12 个欧洲国家的连续 RA 患者，以检验不同组合的仪器可能包含在 RAID 组合量表（数字评定量表（NRS）或各种问卷）中的心理测量学特性。通过 Spearman 相关系数评估结构效度，通过 50 例稳定患者的组内相关系数（ICC）评估信度，通过 88 例治疗强化患者的标准化反应均值（SRM）评估对变化的敏感性。
570 例患者（79%为女性，平均年龄±标准差为 56±13 岁，病程 12.5±10.3 年，疾病活动评分（DAS28）4.1±1.6）参与了验证研究。NRS 问题的表现与较长的问卷组合一样好：最终的 RAID 评分由七个 NRS 问题组成。最终的 RAID 与患者整体（R=0.76）显著相关，与其他结果（DAS28 R=0.69、36 健康调查简表躯体部分-0.59 和精神部分-0.55，p<0.0001）也显著相关。信度高（ICC 0.90；95%CI 0.84 至 0.94），变化敏感性良好（SRM 0.98（0.96 至 1.00）与 DAS28 SRM 1.06（1.01 至 1.11）相比）。
RAID 评分是一种患者衍生的综合评分，评估了 RA 影响的七个最重要领域。该评分现已验证；变化敏感性应在更大的研究中进一步检验。
