乳腺癌患者焦虑和抑郁水平与新辅助化疗反应的相关性
The correlation of anxiety and depression levels with response to neoadjuvant chemotherapy in patients with breast cancer.
作者信息
Gogne Anupriya, Khandelwal Rohan, Tandon Megha, Jain Sidharth, Kumar Yashwant, Narayan Nikhil, Bamal Rahul, Srinivas S, Saxena Sunita
机构信息
VMMC, Safdarjang Hospital New Delhi - Surgery , New Delhi.
出版信息
JRSM Short Rep. 2011 Mar 14;2(3):15. doi: 10.1258/shorts.2010.010072.
BACKGROUND
The aim was to evaluate and correlate anxiety and depression levels with response to neoadjuvant chemotherapy in patients with breast cancer. The study also assessed the effects of family support on distress levels.
DESIGN
It was a prospective study in a cohort of 84 patients with locally advanced breast cancer. These assessments were done using the Hospital Anxiety and Depression Scale (HADS).
SETTING
A prospective study in a developing world setting.
PARTICIPANTS
Eighty-four patients with locally advanced breast cancer receiving neoadjuvant chemotherapy were included after taking an informed consent and ethical committee clearance.
MAIN OUTCOME MEASURES
A significant correlation was observed between response to neoadjuvant chemotherapy and depression levels in breast cancer patients. Joint family and literacy levels also had an impact on the levels of depression observed.
RESULTS
A total of 84 patients receiving neoadjuvant chemotherapy for breast cancer were evaluated using HADS. The effect of family support, literacy levels and employment on the psychological status of these patients were also assessed.
CONCLUSIONS
The response to neoadjuvant chemotherapy had a direct correlation with the levels of depression, the distress levels being lower in responders. This was found to be the most important variable determining the psychological status of the patients. It was also observed that Indian patients in comparison to their Western counterparts react differently to cancer-related stress.
背景
目的是评估乳腺癌患者的焦虑和抑郁水平，并将其与新辅助化疗的反应相关联。该研究还评估了家庭支持对痛苦程度的影响。
设计
这是一项针对84例局部晚期乳腺癌患者的前瞻性研究。这些评估使用医院焦虑抑郁量表（HADS）进行。
背景
在发展中世界环境下的一项前瞻性研究。
参与者
84例接受新辅助化疗的局部晚期乳腺癌患者在获得知情同意和伦理委员会批准后被纳入研究。
主要观察指标
观察到乳腺癌患者对新辅助化疗的反应与抑郁水平之间存在显著相关性。联合家庭和识字水平也对观察到的抑郁水平有影响。
结果
共使用HADS对84例接受乳腺癌新辅助化疗的患者进行了评估。还评估了家庭支持、识字水平和就业对这些患者心理状态的影响。
结论
对新辅助化疗的反应与抑郁水平直接相关，反应者的痛苦程度较低。这被发现是决定患者心理状态的最重要变量。还观察到，与西方患者相比，印度患者对癌症相关压力的反应不同。
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