7,8-O-异丙叉基艾里莫醇内酯-3a 的立体选择性全合成
A stereoselective total synthesis of 7,8-O-isopropylidene iriomoteolide-3a.
机构信息
Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, P. R. China.
出版信息
Org Biomol Chem. 2011 Jun 21;9(12):4518-26. doi: 10.1039/c0ob01253j. Epub 2011 May 3.
PMID:21541369
Abstract
A stereoselective total synthesis of 7,8-O-isopropylidene iriomoteolide-3a has been achieved by using Yamaguchi esterification, Julia-Kocienski olefination, organocatalytic α-oxidation, and ring-closing metathesis reaction as key bond-forming steps.
摘要
通过使用 Yamaguchi 酯化反应、Julia-Kocienski 烯烃化反应、有机催化的α-氧化反应和环化复分解反应作为关键键形成步骤，实现了 7,8-O-异丙叉基ir 合成的立体选择性全合成。
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