Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland.
Dalton Trans. 2011 Jul 21;40(27):7061-76. doi: 10.1039/c0dt01706j. Epub 2011 May 3.
Peptide Nucleic Acids (PNAs) are non-natural DNA/RNA analogues with favourable physico-chemical properties and promising applications. Discovered nearly 20 years ago, PNAs have recently re-gained quite a lot of attention. In this Perspective article, we discuss the latest advances on the preparation and utilisation of PNA monomers and oligomers containing metal complexes. These metal- conjugates have found applications in various research fields such as in the sequence-specific detection of nucleic acids, in the hydrolysis of nucleic acids and peptides, as radioactive probes or as modulators of PNA·DNA hybrid stability, and last but not least as probes for molecular and cell biology.
肽核酸 (PNA) 是具有良好理化性质和广阔应用前景的非天然 DNA/RNA 类似物。近 20 年前发现的 PNA 最近又重新引起了广泛关注。在这篇观点文章中，我们讨论了制备和利用含有金属配合物的 PNA 单体和寡聚物的最新进展。这些金属缀合物已在各种研究领域得到应用，例如核酸的序列特异性检测、核酸和肽的水解、放射性探针或 PNA·DNA 杂交稳定性调节剂，以及最后但并非最不重要的作为分子和细胞生物学的探针。
