Pignataro L, Capaccio P, Pruneri G, Carboni N, Fracchiolla N, Richelda R, Scaramellini G, Neri A, Buffa R
UNIV MILAN,OSPED MAGGIORE,IRCCS,SERV ANAT PATOL 2,I-20122 MILAN,ITALY. UNIV MILAN,OSPED MAGGIORE,IRCCS,IST SCI MED,SERV EMATOL,LAB EMATOL SPERIMENTALE & GENET MOL,I-20122 MILAN,ITALY.
Int J Oncol. 1996 Sep;9(3):553-7. doi: 10.3892/ijo.9.3.553.
The prognosis of patients carrying glottic squamous cell carcinomas (GSCCs) involving the anterior commissure is often unpredictable. In order to assess the possible prognostic role of new and reliable parameters, p53 and cyclin D1 protein expression was immunohistochemically analysed in pathological samples from 27 patients with GSCG (pTlbNOMO) and a median follow-up of 90 months. p53 protein expression was observed in the majority of patients (15/27), but it did not correlate with their clinical outcome; p53 protein immunoreactivity was frequently observed in normal (9/14), mildy dysplastic (10/14) and highly dysplastic (3/7) mucosa samples, suggesting that its overexpression may be involved in the earliest phases of the multistep tumourigenesis of laryngeal squamous cell carcinomas (LSCCs); neither the non-neoplastic nor the neoplastic samples expressed any cyclin D1. As cyclin D1 protein expression has been associated with a high frequency of nodal metastases, its absence in our series could ba related to the rarity of nodal involvement in early glottic LSCCs.
累及前联合的声门鳞状细胞癌（GSCC）患者的预后通常难以预测。为了评估新的可靠参数的可能预后作用，对27例声门鳞状细胞癌（pTlbN0M0）患者的病理样本进行免疫组织化学分析，检测p53和细胞周期蛋白D1蛋白表达情况，并进行了为期90个月的中位随访。多数患者（15/27）观察到p53蛋白表达，但它与患者的临床结局无关；在正常黏膜样本（9/14）、轻度发育异常黏膜样本（10/14）和高度发育异常黏膜样本（3/7）中经常观察到p53蛋白免疫反应性，提示其过表达可能参与喉鳞状细胞癌（LSCC）多步骤肿瘤发生的最早阶段；非肿瘤样本和肿瘤样本均未表达任何细胞周期蛋白D1。由于细胞周期蛋白D1蛋白表达与高频率的淋巴结转移相关，在我们的研究系列中未观察到其表达可能与早期声门LSCCs中淋巴结受累罕见有关。
