通过基于人群的免疫化学粪便潜血检测筛查计划检测出的结直肠癌患者的生存获益。

Survival benefit for patients with colorectal cancer detected by population-based screening program using an immunochemical fecal occult blood test.

作者信息

Wada T, Saito H, Soma Y, Koeda J, Kawaguchi H, Tanaka M, Yoshida Y, Munakata A

机构信息

HIROSAKI UNIV,SCH MED,DEPT INTERNAL MED 1,HIROSAKI,AOMORI 036,JAPAN. HIROSAKI UNIV,SCH MED,DEPT PATHOL 2,HIROSAKI,AOMORI 036,JAPAN.

出版信息

Int J Oncol. 1996 Oct;9(4):685-91. doi: 10.3892/ijo.9.4.685.

DOI:10.3892/ijo.9.4.685

PMID:21541569

Abstract

The effectiveness of screening for colorectal cancer by an immunochemical fecal occult blood test was investigated by comparing the survival time of 194 screen-detected colorectal cancer subjects (screen-detected group) with that of 352 routinely diagnosed subjects (control group). The rate of Dukes' A cancers was significantly higher in screen-detected group than in the control group (43.8% vs 16.8%, p<0.0001), whereas that of Dukes' D cancer was the opposite (5.7% vs 21.3%, p<0.0001). The survival rate for screen-detected group was higher than that for the control group (Kaplan-Meier method, p<0.0001). By a proportional hazard model with adjustment for prognostic factors except stage, the risk ratio of death from colorectal cancer was 0.40 (p=0.0007) for screen-detected group versus the control group. Therefore, the screening was suggested to be effective in survival benefit, although there might be potential biases inherent in observational studies.

摘要

通过比较194名经筛查发现的结直肠癌患者（筛查发现组）和352名常规诊断患者（对照组）的生存时间，研究了免疫化学粪便潜血试验筛查结直肠癌的有效性。筛查发现组中杜克A期癌症的比例显著高于对照组（43.8%对16.8%，p<0.0001），而杜克D期癌症的比例则相反（5.7%对21.3%，p<0.0001）。筛查发现组的生存率高于对照组（Kaplan-Meier法，p<0.0001）。通过对除分期外的预后因素进行调整的比例风险模型，筛查发现组与对照组相比，结直肠癌死亡的风险比为0.40（p=0.0007）。因此，尽管观察性研究可能存在潜在偏差，但该筛查被认为在生存获益方面是有效的。