Yagasaki R, Noguchi M, Minami M, Earashi M
KANAZAWA UNIV HOSP,SCH MED,OPERAT CTR,KANAZAWA,ISHIKAWA 920,JAPAN. KANAZAWA UNIV HOSP,SCH MED,DEPT SURG 2,KANAZAWA,ISHIKAWA 920,JAPAN.
Int J Oncol. 1996 Oct;9(4):755-61. doi: 10.3892/ijo.9.4.755.
We examined the clinical significance of E-cadherin and vimentin expression in 83 patients with breast dancer. E-cadherin expression was correlated with axillary metastases, histologic grade, recurrence and disease-free survival, but not with overall survival. On the other hand, vimentin expression was correlated with axillary metastases and histologic grade, but not with recurrence, disease-free or overall survival. However, the co-expression of E-cadherin and vimentin was associated with axillary metastases, histologic grade and recurrence, and appeared as the most important prognostic factor in disease-free and overall survival. We therefore concluded that E-cadherin and vimentin expression in combination might provide prognostic information for breast cancer patients.
我们检测了83例乳腺癌患者中E-钙黏蛋白和波形蛋白表达的临床意义。E-钙黏蛋白的表达与腋窝转移、组织学分级、复发及无病生存期相关，但与总生存期无关。另一方面，波形蛋白的表达与腋窝转移和组织学分级相关，但与复发、无病生存期或总生存期无关。然而，E-钙黏蛋白和波形蛋白的共表达与腋窝转移、组织学分级和复发相关，并且似乎是无病生存期和总生存期最重要的预后因素。因此，我们得出结论，E-钙黏蛋白和波形蛋白的联合表达可能为乳腺癌患者提供预后信息。
