Wilson R W, Chenggis M L, Unger E R
Winship Cancer Center, Atlanta, Ga 30322.
Arch Pathol Lab Med. 1990 Feb;114(2):155-9.
The recurrence and/or persistence of human papillomavirus (HPV)-associated lesions constitute a well-recognized clinical problem; yet, few studies have demonstrated and typed the HPV within these recurrence lesions. A patient with a 17-year history of anogenital condylomata presented with an unusual bladder tumor that had histologic features of HPV infection. This prompted a longitudinal analysis of HPV DNA in archival material from these urogenital lesions. Colorimetric in situ hybridization was used to assay for HPV types 6, 11, 16, and 18. Human papillomavirus types 6 and 11 were present throughout the period of follow-up in all the condylomatous lesions, including those identified in the bladder, suggesting a common source of infection and spread. By contrast, HPV type 16 was associated only with the vaginal intraepithelial neoplasia that was identified midway through the period of follow-up, and it was apparently cured by excision of the lesion.
人乳头瘤病毒（HPV）相关病变的复发和/或持续存在是一个公认的临床问题；然而，很少有研究在这些复发病变中对HPV进行鉴定和分型。一名有17年肛门生殖器尖锐湿疣病史的患者出现了一种具有HPV感染组织学特征的罕见膀胱肿瘤。这促使对这些泌尿生殖系统病变存档材料中的HPV DNA进行纵向分析。采用比色原位杂交法检测HPV 6、11、16和18型。在所有尖锐湿疣病变（包括膀胱中的病变）的整个随访期间均存在HPV 6和11型，提示存在共同的感染源和传播途径。相比之下，HPV 16型仅与随访期间中期发现的阴道上皮内瘤变相关，并且通过病变切除显然已治愈。
