Department of Neurology, Multiple Sclerosis Outpatient Clinic, Cantonal Hospital St. Gallen, Rorschacher Strasse 95, 9000 St. Gallen, Szitzerland.
Swiss Med Wkly. 2011 May 3;141:w13192. doi: 10.4414/smw.2011.13192. eCollection 2011.
Vitamin D levels have not been previously published for Swiss multiple sclerosis (MS) patients. An association between vitamin D status and disease activity in MS has been suggested.
To define 25-hydroxy-vitamin D (25(OH)D) levels in Swiss multiple sclerosis patients.
Cross sectional case control study.
25(OH)D levels of 80 patients (76.3% female, mean age 37.9 ± 10.6 years, mean Expanded Disability Status Scale (EDSS) 2.6 ± 1.2) were collected. Mean levels of 25(OH)D were 57.0 ± 29.7 nmol/l (range 18-175 nmol/l) in all patients. A total of 21.3% of patients had levels ≤37 nmol/l and 75% had levels ≤70 nmol/l. 25(OH)D levels in patients with previous high disease activity were 52.8 ± 23.1 nmol/l versus 58.9 ± 32.3 nmol/l in the low disease activity group (p = 0.4).
The prevalence of 25(OH)D deficiency was high in Swiss MS patients.
此前尚未公布瑞士多发性硬化症 (MS) 患者的维生素 D 水平。有人提出维生素 D 状况与 MS 疾病活动之间存在关联。
确定瑞士多发性硬化症患者的 25-羟维生素 D（25(OH)D）水平。
横断面病例对照研究。
共收集了 80 名患者（76.3%为女性，平均年龄 37.9 ± 10.6 岁，平均扩展残疾状况量表 (EDSS) 2.6 ± 1.2）的 25(OH)D 水平。所有患者的 25(OH)D 平均水平为 57.0 ± 29.7 nmol/l（范围 18-175 nmol/l）。共有 21.3%的患者水平≤37 nmol/l，75%的患者水平≤70 nmol/l。既往高疾病活动患者的 25(OH)D 水平为 52.8 ± 23.1 nmol/l，而低疾病活动组为 58.9 ± 32.3 nmol/l（p=0.4）。
瑞士多发性硬化症患者 25(OH)D 缺乏症的患病率较高。
