瑞士多发性硬化症患者的维生素 D 水平。
Vitamin D levels in Swiss multiple sclerosis patients.
机构信息
Department of Neurology, Multiple Sclerosis Outpatient Clinic, Cantonal Hospital St. Gallen, Rorschacher Strasse 95, 9000 St. Gallen, Szitzerland.
出版信息
Swiss Med Wkly. 2011 May 3;141:w13192. doi: 10.4414/smw.2011.13192. eCollection 2011.
BACKGROUND
Vitamin D levels have not been previously published for Swiss multiple sclerosis (MS) patients. An association between vitamin D status and disease activity in MS has been suggested.
AIM
To define 25-hydroxy-vitamin D (25(OH)D) levels in Swiss multiple sclerosis patients.
METHOD
Cross sectional case control study.
RESULTS
25(OH)D levels of 80 patients (76.3% female, mean age 37.9 ± 10.6 years, mean Expanded Disability Status Scale (EDSS) 2.6 ± 1.2) were collected. Mean levels of 25(OH)D were 57.0 ± 29.7 nmol/l (range 18-175 nmol/l) in all patients. A total of 21.3% of patients had levels ≤37 nmol/l and 75% had levels ≤70 nmol/l. 25(OH)D levels in patients with previous high disease activity were 52.8 ± 23.1 nmol/l versus 58.9 ± 32.3 nmol/l in the low disease activity group (p = 0.4).
CONCLUSION
The prevalence of 25(OH)D deficiency was high in Swiss MS patients.
背景
此前尚未公布瑞士多发性硬化症 (MS) 患者的维生素 D 水平。有人提出维生素 D 状况与 MS 疾病活动之间存在关联。
目的
确定瑞士多发性硬化症患者的 25-羟维生素 D（25(OH)D）水平。
方法
横断面病例对照研究。
结果
共收集了 80 名患者（76.3%为女性，平均年龄 37.9 ± 10.6 岁，平均扩展残疾状况量表 (EDSS) 2.6 ± 1.2）的 25(OH)D 水平。所有患者的 25(OH)D 平均水平为 57.0 ± 29.7 nmol/l（范围 18-175 nmol/l）。共有 21.3%的患者水平≤37 nmol/l，75%的患者水平≤70 nmol/l。既往高疾病活动患者的 25(OH)D 水平为 52.8 ± 23.1 nmol/l，而低疾病活动组为 58.9 ± 32.3 nmol/l（p=0.4）。
结论
瑞士多发性硬化症患者 25(OH)D 缺乏症的患病率较高。
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