Eskandari Ghazaleh, Ghajarzadeh Mahsa, Yekaninejad Mir Saeed, Sahraian Mohammad Ali, Gorji Razieh, Rajaei Faezeh, Norouzi-Javidan Abbas, Faridar Alireza, Azimi Amirreza
Brain and Spinal Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Iran J Neurol. 2015 Apr 4;14(2):81-5.
Multiple sclerosis (MS) is an autoimmune, neuro-inflammatory disease of central nervous system affecting physical, emotional, and cognitive aspects of patients. Association of vitamin D deficiency and MS has been shown in previous studies. The aim of this study was to evaluate serum vitamin D level in MS cases and their sex-matched healthy siblings (who are genetically near similar) and non-relative sex-matched healthy controls.
A total of 135 subjects enrolled in this case-control study. Group one (n = 45) consisted of patients with established MS. Group two (n = 45) included sex-matched healthy siblings of the group one and group three participants (n = 45) were non-relative sex-matched healthy controls. Demographic data (age, sex), level of education, daily sun exposure duration, and month of birth gathered for all. Serum sample of all participants was collected for 25-hydroxy vitamin D measurement.
There was no significant difference between vitamin D level, sun exposure duration, education level, and season of birth in three evaluated groups. Mean vitamin D level was 8.2 ± 10.1 (nmol/l) in women and 13.3 ± 7 (nmol/l) in men (P = 0.001). There was a significant positive correlation between daily sun exposure duration and vitamin D level in whole participants (r = 0.28, P < 0.001) as well as in MS patients (r = 0.32, P = 0.030). Mean vitamin D level was significantly lower in participants who have born in spring and summer.
Vitamin D deficiency is high among Iranian population as well as MS patients.
多发性硬化症（MS）是一种影响患者身体、情感和认知方面的中枢神经系统自身免疫性神经炎症性疾病。先前的研究已表明维生素D缺乏与MS之间存在关联。本研究的目的是评估MS患者及其性别匹配的健康同胞（基因相似度接近）以及非亲属性别匹配的健康对照者的血清维生素D水平。
本病例对照研究共纳入135名受试者。第一组（n = 45）由确诊的MS患者组成。第二组（n = 45）包括第一组性别匹配的健康同胞，第三组参与者（n = 45）为非亲属性别匹配的健康对照者。收集了所有人的人口统计学数据（年龄、性别）、教育水平、每日日照时长和出生月份。采集了所有参与者的血清样本以测量25-羟维生素D。
在三个评估组中，维生素D水平、日照时长、教育水平和出生季节之间无显著差异。女性的平均维生素D水平为8.2±10.1（nmol/l），男性为13.3±7（nmol/l）（P = 0.001）。在所有参与者中（r = 0.28，P < 0.001）以及MS患者中（r = 0.32，P = 0.030），每日日照时长与维生素D水平之间存在显著正相关。在春季和夏季出生的参与者中，平均维生素D水平显著较低。
伊朗人群以及MS患者中维生素D缺乏情况严重。
