Department of Neurology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
Department of Clinical Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.
Mult Scler Relat Disord. 2018 Oct;25:329-333. doi: 10.1016/j.msard.2018.08.030. Epub 2018 Aug 31.
Vitamin D deficiency is commonly found in multiple sclerosis (MS) and Neuromyelitis Optic (NMO) patients and can impair the immunological status. As a tropical country, Indonesia has a lot of sunshine throughout the year as a source of vitamin D. The aim of this study was to evaluate and compare the serum vitamin D-25(OH) level in Indonesian MS and NMO patients to healthy individuals.
A cross-sectional study was conducted in Dr. Cipto Mangunkusumo General Hospital Jakarta from November 2016 to May 2017. Forty-eight patients (29 MS and 19 NMO) and 33 healthy controls were enrolled. We assessed the dietary recall, vitamin D supplementation, sunshine exposure, medication, annual relapse rate, and Expanded Disability Status Scale (EDSS). Vitamin D level was measured using direct competitive chemiluminescence immunoassay.
Vitamin D deficiency was found in 48.4% of MS and 56.2% of NMO patients. The serum vitamin D level in MS and NMO groups was not significantly different from the healthy controls. Vitamin D level was not associated with EDSS and the annual relapse rate. Positive significant correlation was observed between sunshine exposure and vitamin D level in healthy control, but not evident in MS and NMO groups. MS and NMO subjects who still treated with corticosteroid had lower vitamin D level.
Vitamin D deficiency is commonly found in Indonesian MS and NMO patients, but not associated with EDSS and annual relapse rate. Despite living in a country with adequate sunshine exposure, the physician should anticipate low serum vitamin D level, especially in MS or NMO patients who received corticosteroid.
维生素 D 缺乏症在多发性硬化症（MS）和视神经脊髓炎（NMO）患者中很常见，会损害免疫状态。印度尼西亚作为一个热带国家，全年阳光充足，是维生素 D 的来源。本研究旨在评估和比较印度尼西亚 MS 和 NMO 患者与健康个体的血清维生素 D-25（OH）水平。
这是一项 2016 年 11 月至 2017 年 5 月在雅加达 Cipto Mangunkusumo 综合医院进行的横断面研究。共纳入 48 例患者（29 例 MS 和 19 例 NMO）和 33 名健康对照者。我们评估了饮食回忆、维生素 D 补充剂、阳光照射、药物、年复发率和扩展残疾状况量表（EDSS）。使用直接竞争化学发光免疫测定法测量维生素 D 水平。
MS 和 NMO 患者分别有 48.4%和 56.2%存在维生素 D 缺乏。MS 和 NMO 组的血清维生素 D 水平与健康对照组无显著差异。维生素 D 水平与 EDSS 和年复发率无关。在健康对照组中，阳光照射与维生素 D 水平呈正相关，但在 MS 和 NMO 组中不明显。仍接受皮质类固醇治疗的 MS 和 NMO 患者维生素 D 水平较低。
印度尼西亚 MS 和 NMO 患者普遍存在维生素 D 缺乏症，但与 EDSS 和年复发率无关。尽管生活在阳光充足的国家，但医生应预料到血清维生素 D 水平较低，尤其是接受皮质类固醇治疗的 MS 或 NMO 患者。
