尿酸作为多系统萎缩症患者潜在的疾病修饰因子。
Uric acid as a potential disease modifier in patients with multiple system atrophy.
机构信息
Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.
出版信息
Mov Disord. 2011 Jul;26(8):1533-6. doi: 10.1002/mds.23556. Epub 2011 May 3.
BACKGROUND
Recent studies have suggested that mitochondrial dysfunction and oxidative stress play a key role in the pathogenesis of multiple system atrophy.
METHODS
We evaluated the influence of serum uric acid levels on disease progression in 52 patients with multiple system atrophy using changes in the annualized Unified Multiple System Atrophy Rating Scale scores.
RESULTS
The mean annualized Unified Multiple System Atrophy Rating Scale changes were significantly lower in patients with the highest uric acid quartile compared with those with the lowest quartile (8.4 ± 5.1 vs 20.2 ± 16.0, P = .038). Serum uric acid levels had a significant negative correlation with the annualized Unified Multiple System Atrophy Rating Scale changes (r = -0.40, P = .004). Multiple linear regression analysis showed that only serum uric acid concentration was significantly correlated with the annualized Unified Multiple System Atrophy Rating Scale changes (β = -2.687, P = .011).
CONCLUSIONS
These data suggest that serum uric acid may act as a potential disease modifier in multiple system atrophy.
背景
最近的研究表明，线粒体功能障碍和氧化应激在多系统萎缩的发病机制中起关键作用。
方法
我们通过年度统一多系统萎缩评定量表评分的变化来评估 52 例多系统萎缩患者血清尿酸水平对疾病进展的影响。
结果
与尿酸最低四分位组相比，尿酸最高四分位组的患者年度统一多系统萎缩评定量表评分变化明显较低（8.4±5.1 比 20.2±16.0，P=0.038）。血清尿酸水平与年度统一多系统萎缩评定量表评分变化呈显著负相关（r=-0.40，P=0.004）。多元线性回归分析显示，只有血清尿酸浓度与年度统一多系统萎缩评定量表评分变化显著相关（β=-2.687，P=0.011）。
结论
这些数据表明，血清尿酸可能是多系统萎缩的潜在疾病修饰因子。
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