尿酸水平及尿酸/肌酐比值与帕金森病分期的相关性
Level of uric acid and uric acid/creatinine ratios in correlation with stage of Parkinson disease.
作者信息
Zhong Ling-Ling, Song Ya-Qi, Tian Xiang-Yang, Cao Hua, Ju Ke-Ju
机构信息
Department of Neurology Department of Radiation Oncology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University Department of Hematology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu, P.R. China.
出版信息
Medicine (Baltimore). 2018 Jun;97(26):e10967. doi: 10.1097/MD.0000000000010967.
This study aims to investigate relationship between the level of uric acid (UA) and UA/creatinine ratios (UA/Cr) to the stage of Parkinson disease (PD).A total of 120 cases of PD patients who were admitted in our hospital between 2013 and 2015 were enrolled into this study; these 120 cases of PD patients were divided into 3 groups, according to Hoehn-Yahr (H-Y) classification: early stage (1-2 classification), medium stage (2.5-3 classification), and advanced stage (4-5 classification); UA and UA/Cr level in each group was compared. Then, factors including age, gender, dopamine dosage, UA, and UA/Cr levels were analyzed to find the independent predictive factors of PD by logistic regression.UA and UA/Cr levels in the early and medium stage PD patients were significantly higher than in the advanced stage ones. UA and UA/Cr levels in patients with good prognosis were significantly higher than in the poor ones.UA and UA/Cr levels are negatively correlated with the stages of PD and are independent negatively predicting biological indexes of PD incidence and progression.
本研究旨在探讨尿酸（UA）水平及尿酸/肌酐比值（UA/Cr）与帕金森病（PD）分期之间的关系。选取2013年至2015年期间我院收治的120例PD患者纳入本研究；将这120例PD患者根据Hoehn-Yahr（H-Y）分级分为3组：早期（1-2级）、中期（2.5-3级）和晚期（4-5级）；比较每组患者的UA及UA/Cr水平。然后，对年龄、性别、多巴胺用量、UA及UA/Cr水平等因素进行分析，通过逻辑回归确定PD的独立预测因素。早期和中期PD患者的UA及UA/Cr水平显著高于晚期患者。预后良好患者的UA及UA/Cr水平显著高于预后较差者。UA及UA/Cr水平与PD分期呈负相关，是PD发生和进展的独立负性预测生物学指标。
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