血清尿酸水平与多系统萎缩男性患者的疾病进展速率相关。
Serum uric acid level is linked to the disease progression rate in male patients with multiple system atrophy.
作者信息
Fukae Jiro, Fujioka Shinsuke, Yanamoto Shosaburo, Mori Akio, Nomi Takahiro, Hatano Taku, Fukuhara Kousuke, Ouma Shinji, Hattori Nobutaka, Tsuboi Yoshio
机构信息
Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan; Department of Neurology, Fukuoka University School of Medicine, Fukuoka, Japan.
Department of Neurology, Fukuoka University School of Medicine, Fukuoka, Japan.
出版信息
Clin Neurol Neurosurg. 2017 Jul;158:15-19. doi: 10.1016/j.clineuro.2017.04.002. Epub 2017 Apr 3.
OBJECTIVES
Multiple system atrophy (MSA) is a progressive neurodegenerative disorder that may be caused in part by oxidative stress. Uric acid (UA) protects neurons in neurodegenerative disorders via antioxidative effects. The aim of this study was to investigate the relationship between the serum UA concentration and disease progression in MSA patients.
PATIENTS AND METHODS
A total of 53 Japanese MSA patients were enrolled in this study. The disease progression rate was estimated by the rate of global disability scale change per year. The relationship between the serum UA concentration and disease progression was assessed by Spearman's correlation analysis. Disease progression depending on the UA concentration was also estimated by multivariate logistic regression analysis.
RESULTS
MSA patients with the highest serum UA concentration had lower disease progression rates than those with the lowest concentration. Spearman's correlation analysis showed an inverse correlation between the serum UA concentration and disease progression in male patients. Multivariate logistic regression analysis confirmed that the UA concentration was independently related to disease progression only in male patients.
CONCLUSION
These results suggest that serum UA may be associated with disease progression in male patients with MSA.
目的
多系统萎缩（MSA）是一种进行性神经退行性疾病，部分可能由氧化应激引起。尿酸（UA）通过抗氧化作用保护神经退行性疾病中的神经元。本研究的目的是探讨MSA患者血清尿酸浓度与疾病进展之间的关系。
患者和方法
本研究共纳入53例日本MSA患者。疾病进展率通过每年全球残疾量表变化率来估计。血清尿酸浓度与疾病进展之间的关系通过Spearman相关性分析进行评估。还通过多因素逻辑回归分析估计了取决于尿酸浓度的疾病进展情况。
结果
血清尿酸浓度最高的MSA患者的疾病进展率低于浓度最低的患者。Spearman相关性分析显示男性患者血清尿酸浓度与疾病进展呈负相关。多因素逻辑回归分析证实，仅在男性患者中尿酸浓度与疾病进展独立相关。
结论
这些结果表明，血清尿酸可能与男性MSA患者的疾病进展有关。
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