刺桐中的抗结核查耳酮和类黄酮。

Antitubercular chromones and flavonoids from Pisonia aculeata.

机构信息

Graduate Institute of Natural Products, Department of Biomedical Laboratory Science and Biotechnology, School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan 807, Republic of China.

出版信息

J Nat Prod. 2011 May 27;74(5):976-82. doi: 10.1021/np1008575. Epub 2011 May 4.

DOI:10.1021/np1008575

PMID:21542597

Abstract

Three new chromones, pisonins A (1), B (2), and D (4), two new flavonoids, pisonivanone [(2S)-5,7,2'-trihydroxy-8-methylflavanone] (7) and pisonivanol [(2R,3R)-3,7-dihydroxy-5,6-dimethoxyflavanone] (8), one new isoflavonoid, pisonianone (5,7,2'-trihydroxy-6-methoxy-8-methylisoflavone) (9), and five compounds first isolated from nature, namely, pisonins C (3), E (5), and F (6), pisoniamide (10), and pisonolic acid (11), together with 18 known compounds have been isolated from the methanol extract of the combined stem and root of Pisonia aculeata. Among these isolates, 2, 7, 14, 16, and 19 exhibited antitubercular activities (MICs≤50.0 μg/mL) against Mycobacterium tuberculosis H37Rv in vitro.

摘要

从刺桐的茎和根的甲醇提取物中分离得到了三个新的色酮，即 pisonin A（1）、B（2）和 D（4），两个新的黄酮类化合物，pisonivanone [(2S)-5,7,2'-trihydroxy-8-methylflavanone]（7）和 pisonivanol [(2R,3R)-3,7-dihydroxy-5,6-dimethoxyflavanone]（8），一个新的异黄酮，pisonianone（5,7,2'-trihydroxy-6-methoxy-8-methylisoflavone）（9），以及五个首次从自然界中分离得到的化合物，即 pisonins C（3）、E（5）和 F（6）、pisoniamide（10）和 pisonolic acid（11），连同 18 种已知化合物。在这些分离物中，2、7、14、16 和 19 对结核分枝杆菌 H37Rv 在体外显示出抗结核活性（MICs≤50.0 μg/mL）。